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Pattern of expression of the transcription factor Krox-20 in mouse hair follicle

Domenii publicaţii > Biologie + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: Gambardella L, Schneider-Maunoury S, Voiculescu O, Charnay P, Barrandon Y

Editorial: Mech Dev, 96(2), p.215-218, 2000.

Rezumat:

We examined the pattern of expression in hair follicles of the transcription factor gene Krox-20. During embryogenesis, Krox-20 is first expressed in the upper portion of the hair bud, then in the hair canal, in the sebaceous glands and in the outer root sheath. In the mature follicles, Krox-20, like Shh and TGFRII, is also expressed in a sub-population of matrix keratinocytes located in a ring-like fashion in vibrissal follicles and clustered on one side of the papilla in pelage follicles. This polarized pattern rotates around the papilla as a result of sequential gene expression by individual groups of matrix cells. This peculiar pattern is not linked to follicle angling.

Cuvinte cheie: Embryogenesis, Mouse hair follicles, Transcription factor Krox-20

URL: http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T9H-411PGV4-7-9&_cdi=5115&_user=125795&_orig=search&_coverDate=09%2F30%2F2000&_qd=1&_sk=999039997&view=c&wchp=dGLbVzz-zSkzV&md5=1eeb3681e2e33b45ba93d2088a87a30a&ie=/sdarticle.pdf