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Syntheses of 2-Alkylamino- and 2-Dialkylamino-4,6-diarylpyridines and 2,4,6-Trisubstituted Pyrimidines Using Solid-Phase-Bound Chalcones

Domenii publicaţii > Chimie + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: Katritzky, Alan R.; Serdyuk, Larisa; Chassaing, Christophe; Toader, Dorin; Wang, Xiaojing; Forood, Behrouz; Flatt, Brenton; Sun, Congcong; Vo, Kim

Editorial: J. Comb. Chem., 2(2), p.182-185, 2000.

Rezumat:

Several substituted 2- and 4-hydroxyacetophenones are linked to Wang resin via a modified Mitsunobu protocol. These resin-bound acetophenones are condensed with arom. aldehydes, and the resulting chalcones are used for the synthesis of 2-dialkylamino- and 2-alkylamino-4,6-diarylpyridines, and 2-alkyl-4,6-diaryl- and 2,4,6-triarylpyrimidines in a manner suitable for combinatorial applications

Cuvinte cheie: combinatorial chemistry, solid phase synthesis