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Lipophilic Nucelosides by Sonogashira Coupling

Domenii publicaţii > Chimie + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: • Flasche, W., Cismas, C., Herrmann, A., Liebscher, J

Editorial: Synthesis, p.2335-2341, 2004.

Rezumat:

New amphiphilic nucleosides 3, 5, 7, 9 and nucleobases 12, 14, with lipophilic alkinyl substituents attached to the N-heterocyclic ring were obtained in a straight forward manner by Sonogashira-coupling of 5-iodouridine, 8-bromoadenosine and protected 8-bromo-guanosine or related halonucleobases. In most cases protective groups were unnecessary.

Cuvinte cheie: nucleozide, nucleobaze, amfifilic // nucleosides, nucleobases, cross-coupling, amphiphile

URL: http://www.thieme-connect.com/ejournals/pdf/synthesis/doi/10.1055/s-2004-831190.pdf