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Significance of human platelet-activating factor-acetylhydrolase in patients with non-insulin-dependent (type 2) diabetes mellitus

Domenii publicaţii > Ştiinţe medicale + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: M. Serban, C. Tanaseanu, T. Kosaka, C.Vidulescu, I. Stoian, D.S. Marta, S. Tanaseanu, E. Moldoveanu

Editorial: Journal of Cellular and Molecular Medicine, 6, p.643-647, 2002.


Background: Non-insulin dependent diabetes mellitus (NIDDM) represents an independent risk factor for cardiovascular diseases (CVD), being characterized by a continuous low-grade inflammation and endothelial activation state. Plasma platelet – activating factor – acetylhydrolases (PAF-AHs) are a subgroup of Ca2+-independent phospholipase A2 family (also known as lipoprotein-associated phospholipases A2) that hydrolyze and inactivate the lipid mediator platelet-activating factor (PAF) and/or oxidized phospholipids. This enzyme is considered to play an important role in inflammatory diseases and atherosclerosis. The present study aims to investigate the relations between the levels of PAF-AH activity and LDL-cholesterol / HDL-cholesterol (LDL-ch / HDL-ch) ratio in NIDDM patients as compared to controls. Methods: serum PAF-AH activity was measured in 50 patients with dyslipidemia, in 50 NIDDM patients and in 50 controls (normal lipid level, normal glucose level). Total cholesterol, LDL-ch, HDL-ch, triglyceride and blood glucose were determined in all subjects. Results: All NIDDM patients display hiperlipidemia, with increased LDL-ch and triglyceride levels. There is a significant correlation between LDL-ch levels (especially LDL-ch / HDL-ch ratio) and PAF-AH activity in dyslipidemic and NIDDM patients. Conclusion: Diabetic and dyslipidemic patients have an increased plasma PAF-AH activity correlated with their LDL-ch levels and mainly with LDL-ch / HDL-ch ratio. Plasma PAF-AH levels appear to be important as a risk marker for endothelial dysfunction in patients with NIDDM.

Cuvinte cheie: platelet-activating factor acetylhydrolase; non-insulin-dependent diabetes mellitus; endothelial cell dysfunction