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Electrochemical DNA sensors for detection of DNA damage

Domenii publicaţii > Chimie + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: Victor Constantin Diculescu, Ana-Maria Chiorcea Paquim and Ana Maria Oliveira Brett

Editorial: Sensors, 5, p.377, 2005.

Rezumat:

Electrochemical devices have received particular attention due to their rapid detection and great sensitivity for the evaluation of DNA-hazard compounds interaction mechanisms. Several types of bioanalytical method use nucleic acids probes to detect DNA damage. This article reviews current directions and strategies in the development and applications of electrochemical DNA sensors for the detection of DNA damage.

Cuvinte cheie: DNA-electrochemical biosensor, DNA damage, damage to DNA bases, oxidative stress, biomarker of DNA damage, 8-oxo-7,8-dihydroxguanine (8-oxoGua), 8-oxo-7,8-dihydro-2’-deoxyguanosine (8-oxodGuo)