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An alternative approach to amyloid fibrils morphology: CdSe/ZnS quantum dots labelled beta-amyloid peptide fragments Abeta(31–35), Abeta (1–40) and Abeta (1–42)

Domenii publicaţii > Chimie + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: Xiaojun Ji, David Naistat, Changqing Li, Jhony Orbulescu and Roger M. Leblanc

Editorial: Elsevier, Colloids and Surfaces B: Biointerfaces, 2006.

Rezumat:

Abeta(31-35) peptide and control peptides as well as full length Abeta(1-40) and Abeta(1-42) peptides were labelled with luminescent CdSe/ZnS quantum dots (QDs) to observe the morphology of amyloid fibers. A comparison was made between QDs and an organic dye, namely Dansyl group, which showed that the QDs present a much better contrast for imaging than the organic dye.

Cuvinte cheie: beta-amyloid, quantum dots, fluorescence imaging

URL: http://dx.doi.org/10.1016/j.colsurfb.2006.02.010