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Neural crest boundary cap cells constitute a source of neuronal and glial cells of the PNS.

Domenii publicaţii > Biologie + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: Maro GS, Vermeren M, Voiculescu O, Melton L, Cohen J, Charnay P, Topilko P.

Editorial: Nat Neurosci., 7(9), p.930-8, 2004.

Rezumat:

Boundary cap (BC) cells are neural crest derivatives that form clusters at the surface of the neural tube, at entry and exit points of peripheral nerve roots. Using various knock-in alleles of the mouse gene Egr2 (also known as Krox20), the expression of which, in trunk regions, is initially restricted to BC cells, we were able to trace BC cell progeny during development and analyze their fate. Trunk BC-derived cells migrated along peripheral axons and colonized spinal nerve roots and dorsal root ganglia (DRG). All Schwann cell precursors occupying the dorsal roots were derived from BC cells. In the DRG, BC-derived cells were the progenitors of both neurons, mainly nociceptive afferents, and satellite cells. These data indicate that BC cells constitute a source of peripheral nervous system (PNS) components that, after the major neural crest ventrolateral migratory stream, feeds a secondary wave of migration to the PNS.

Cuvinte cheie: peripheral and central nervous system, stem cells, pluripotency

URL: http://www.nature.com/neuro/journal/v7/n9/full/nn1299.html