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Autori: Victor C. Diculescu, Jose Antonio P. Piedade and Ana Maria Oliveira-Brett
Editorial: Bioelectrochemistry, in press, 2006.
The electrochemical behaviour of 2,8-dihydroxyadenine (2,8-DHA)– the main adenine oxidation product– has been investigated over a wide
pH range at a glassy carbon electrode (GCE) using cyclic, differential pulse and square wave voltammetry.
The oxidation of 2,8-DHA is a quasi-reversible process, pH dependent and occurs with the formation of a main oxidation product, P2,8-DHA,
that strongly adsorbs on the electrode surface. The reduction of 2,8-DHA also occurs and is a reversible process in the absence of molecular
oxygen. In electrolytes with pH between 4 and 9 two consecutive reversible charge transfer reactions were identified. However, it was observed
that O2 interfered with the reductive electron transfer process of 2,8-DHA and that, in the presence of oxygen, the reduction of 2,8-DHA occurs at
less negative potentials than in the absence of oxygen.
Cuvinte cheie: Adenine; 2,8-dihydroxyadenine; Oxidation; Reduction; DNA; Oxidative damage; Voltammetry