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Photodynamic therapy: a new concept and a clinical reality for medicine

Domenii publicaţii > Chimie + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: Rodica Mariana Ion

Editorial: Acta Bio-optica et Informatica Medica, 12(1), p.37-49, 2006.

Rezumat:

Photodynamic therapy is an emerging method for local destruction of tumoral tissue by generating toxic oxygen species using light absorbed by an administered photosensitiser. Following administration of a photosensitiser occurs an accumulation or retention in areas of cancer and disease relative to adjacent normal tissue. The photosensitiser is inactive until irradiated by light, following which cellular destruction occurs. This explanation is a good reason for the scientific and clinical interest in photodynamic therapy.
This paper will present an overview of the therapeutic applications of PDT for neoplastic variety of tumors (including ophthalmology, dermatology, neurosurgery) but also in non-cancer applications (such as virus inactivation (herpes simplex), bacteria destruction in dentistry and in dermatology (psoriasis). With a Romanian and an European experience, the author will rezume the most important results obtained on cell culture and in clinical trials. Some considerations about the PDT activity of some sensitizers on different culture cells (in vitro) are discussed.

Cuvinte cheie: Photodynamic therapy(PDT), clinical PDT, porphyrins.