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Spectral Analysis of the Porphyrins Incorporation into Human Blood

Domenii publicaţii > Chimie + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: RM Ion

Editorial: SPIE Digital Library, Journal of Biomedical Optics, 4(3), p.319-326, 1999.

Rezumat:

The porphyrins seem to be the most effective photosensitizers in photodynamic therapy of cancer. Monomers and dimers of sulfonated and nonsulfonated porphyrins [5,10,15,20-tetra-phenyl-porphyrin, 5,10,15,20-tetra-naphtyl-porphyrin (TNP), 5,10,15,20-tetra-p-sulfonato-phenyl-porphyrin (TS4PP) and 5,10,15,20-tetra-p-sulfonato-naphtyl-porphyrin], are studied in this paper by means of different spectral methods (UV-vis, fluorescence and polarization fluorescence). The porphyrins as TNP seem to be the most effective photosensitizer especially in a DMSO:water binary mixture of solvent. Monomer–dimer and J-aggregation equilibria and the temperature dependence of TS4PP spectra are also studied in this paper. The incorporation of the forms of these porphyrins into blood cells is studied by means of the cytofluorimetric method.

Cuvinte cheie: porphyrins, blood, photodynamic therapy

URL: http://spiedl.aip.org