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3D folding in proteins by 1H-1H Solid-State NMR magnetization exchange experiments

Domenii publicaţii > Fizica + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: Oana Zainea, Claudiu Filip

Editorial: Rom. Journ. Phys., 50 (9-10), p.1139–1149, 2005.

Rezumat:

A systematic numerical analysis have been performed for characterizing the
sensitivity of 1H-1H magnetization exchange in providing distance constraints with
relevance for the investigation of protein folding by advanced solid-state NMR
techniques. This was shown to increase by introducing additional initial constraints
within a simplified spin-diffusion approach, for instance based on characteristic
structural features of the investigated class of molecular systems.

Cuvinte cheie: NMR, magnetization exchange, folding, proteins

URL: http://www.nipne.ro/rjp/2005_50_9-10/1139_1150.pdf