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Polymeric biocompatible structures for controlled drug release

Domenii publicaţii > Stiinte ingineresti + Tipuri publicaţii > Articol în volumul unei conferinţe

Autori: T. Zecheru, C. Zaharia, A. Salageanu, C.Tucureanu, E.Rusen,B.Marculescu, T.Rotariu, C.Cincu

Editorial: Conferinta Internationala BIOMMEDD'2006, 2006.

Rezumat:

The purpose of using polymers in drug delivery systems is to be able to create a membrane-like barrier that would control the delivery of the active agent for an extended period. Poly(2-hydroxyethyl methacrylate) (pHEMA), when cross-linked, swells to a significant extent. Hence, it was thought necessary to determine its degree of swelling when incorporating methyl methacrylate (MMA), which is a hydrophobic monomer. The polymeric micro-beads of p(HEMA) and functionalised biopolymers of p(HEMA-co-MMA), p(HEMA-co-AA) and p(HEMA-co-MMA-co-AA) were prepared by precipitant polymerisation method. There were obtained different types of micro-polymeric beads, which were characterised by elemental analysis, measure of the degree of swelling, scanning electron microscopy (SEM). There were also performed in vitro tests, on an L929 line cell. Both physico-chemical and in vitro tests performed gave satisfactorily results.

Cuvinte cheie: drug delivery, swelling, terpolymers, in vitro tests