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Comparative study of some nano- and micro – sensitizers

Domenii publicaţii > Chimie + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: R.M.Ion, M.A.Calin

Editorial: JOURNAL OF OPTOELECTRONICS AND ADVANCED MATERIALS, 9(6), p.1933-1938, 2007.

Rezumat:

The development of new virus inactivation procedures became an area of growing interest mainly due to increased
demands concerning the safety of biological products. Photochemical processes represent the most promising methods for
the future to inactivate viruses. In these methods, dyes are the most widely used photosensitising reagents. The current
article covers a new interesting compound microsensitizer as 5,10,15,20-tetra-sulfonato-phenyl porphyrin (TSPP), and
nanosensitizers, as fullerenes (C60) –coated TSPP suspension (C60/TSPP). There was studied in this paper the
photodynamic inactivation of herpes simplex virus type I (HSV-1) provided from rat, by the above macro and nanosensitizers.
The concentration and temperature effects were evaluated. These sensitizers demonstrate a remarkable
virucidal activity upon light activation, more pronounced for (C60/TSPP) than for TSPP, and after an optimum time of 300
minutes.

Cuvinte cheie: Photodynamic inactivation, Microorganisms, Photosensitizer, fullerenes, Porphyrins