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Hematopoietic Cell Transplantation Directly into Dystrophic Muscle Fails to Reconstitute Satellite Cells and Myofibers

Domenii publicaţii > Ştiinţe medicale + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: Lupu M.*, Kuhr C.S.*, Storb R. (*equal contribution)

Editorial: Biology of Blood and Marrow Transplantation, Aug;13(8), p.886-888, 2007.

Rezumat:

We sought to determine whether wild-type hematopoietic cell transplantation directly into muscle could restore dystrophin expression in a relevant preclinical canine model of Duchenne muscular dystrophy. In recipients rendered tolerant to their dog leukocyte antigen-matched unaffected littermates through hematopoietic stem cell transplantation, intramuscular injection of donor marrow cells produced no evidence of dystrophin expression, and clonal analysis of satellite cells failed to reveal any donor contribution.

Cuvinte cheie: Distrofie musculara Duchenne, transplant de celule stem hematopoietice, maduva osoasa hematogena, plasticitatea celulelor stem hematopoietice, terapie celulara, regenerare musculara, model preclinic canin, medicina translationala // Duchenne muscular dystrophy, hematopoietic cell transplantation, bone marrow, hematopoietic stem cell plasticity, cell therapy, muscle regeneration, preclinical canine model, translational research