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Desensitization of cold- and menthol-sensitive rat dorsal root ganglion neurones by inflammatory mediators.

Domenii publicaţii > Biologie + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: Linte RM, Ciobanu C, Reid G, Babes A

Editorial: Experimental Brain Research, 178(1), p.89-98, 2007.

Rezumat:

The interaction between cold sensitivity
and inflammation in mammals is not entirely understood. We have used adult rat dorsal root ganglion neurones in primary culture together with calcium
microfluorimetry to assess the effects of selected inflammatory mediators on cold responses of cold and menthol-sensitive (most likely TRPM8-expressing)neurones. We observed a high degree of functional
co-expression of TRPM8, the receptors for the inflammatory agents bradykinin, prostaglandin E2 and histamine, and TRPA1 in cultured sensory neurones.
Treatment with either bradykinin or prostaglandin E2 led to a reduction in the amplitude of the response to cooling and shifted the threshold temperature to
colder values, and we provide evidence for a role of protein kinases C and A, respectively, in mediating these effects. In both cases the effects were mainly restricted to the subgroups of cold- and menthol-sensitive cells which had responded to the application of the inflammatory agents at basal temperature. This desensitization of cold-sensitive neurones may enhance inXammatory pain by removing the analgesic effects of gentle cooling.

Cuvinte cheie: durere, inflamatie, trpm8, trpa1, bradikinina, prostaglandina E2, histamina, drg, frig, racire, mentol, imagistica, calciu // pain, trpm8, trpa1, bradykinin, prostaglandin E2, histamine, inflammation, drg, rat, cold, menthol, calcium imaging

URL: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17006682&ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum