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Transglutaminases in Vascular Biology: Relevance for Vascular Remodeling and Atherosclerosis

Domenii publicaţii > Ştiinţe medicale + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: Bakker EN, Pistea A, VanBavel E

Editorial: J Vasc Res, 45(4), p.271-278, 2008.

Rezumat:

The transglutaminase (Tgase) family consists of nine known members of whom at least three are expressed in the vascular system: type 1 Tgase, type 2 Tgase and factor XIII. The cross-linking of proteins is a characteristic feature of Tgases, of well-known importance for stabilizing the blood clot and providing mechanical strength to tissues. However, recent data suggest that Tgases play a role in several other processes in vascular biology. These newly discovered areas include endothelial barrier function, small artery remodeling, and atherosclerosis.

Cuvinte cheie: Transglutaminase, Factor XIII, Vascular remodeling, Atherosclerosis

URL: http://content.karger.com/produktedb/produkte.asp?typ=fulltext&file=000113599