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Identification of People with an Increased Risk of Cancer

Domenii publicaţii > Ştiinţe medicale + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: S. Dragan, M. Puiu, D. Stoicanescu, D. Mihailov

Editorial: Nature Publishing Groupe, European Journal of Human Genetics, 2004.

Rezumat:

Methods of genetic risk assessment include assessment of family history of disease and genetic testing. The aim of the present study was to identify and follow-up individuals at risk for cancer, and their families. Methods: Collecting family history information, using risk factors questionnaire and diet questionnaire. Knowing that women with first- and second-degree affected relatives have a significantly higher risk of developing breast cancer, that the risk increases with the number of affected relatives, younger age of onset, bilateral disease, and the occurrence of ovarian and breast cancer in the same relative within the affected lineage, we investigated the presence of these risk factors within families. Data collected from 300 women from investigated families are stored in order to initiate a cancer registry in the western part of Romania, to establish individuals at risk and the necessary preventing measures. Cancer genetic counseling often involves a multidisciplinary team of health professionals who have expertise in this area. The team may include a genetic counselor, genetic advanced practice nurse or medical geneticist, mental health professional, and medical expert such as oncologist, surgeon, or internist. Cancer genetic counseling may involve several family members, some of whom may have had cancer, and others who have not. In some cases, DNA-based testing can be used to confirm a specific mutation as the cause of the inherited risk, and to determine whether family members have inherited the mutation.

Cuvinte cheie: ovarian and breast cancer, family history, cancer registry

URL: http://www.abstractsonline.com/viewer/SearchResults.asp