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Antitumor activity of liposomal prednisolone phosphate depends on the presence of functional tumor-associated macrophages in tumor tissue.

Domenii publicaţii > Ştiinţe medicale + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: Banciu, M., Metselaar, J. M., Schiffelers, R. M.,Storm, G.

Editorial: Neoplasia, 10 (2), p.108-17, 2008.

Rezumat:

Prednisolone phosphate (PLP) encapsulated in long-circulating liposomes (LCLs) (LCL-PLP) exerts antitumor activity
through the inhibition of tumor angiogenesis. It is known that tumor-associated macrophages (TAMs) play a crucial
role in tumor growth as they are actively involved in promoting and maintaining tumor angiogenesis. To gain more
insight into the antiangiogenic mechanisms of LCL-PLP, this study aimed to investigate the role of TAM in the antitumor
mode of action of LCL-PLP in B16.F10 melanoma-bearing mice. Our results show that TAMs have a pivotal
function in the growth of B16.F10 melanoma through the production of pro-angiogenic/pro-inflammatory factors.
One of the major inhibitory actions of LCL-PLP on tumor growth is the reduction of the TAM-mediated production
of pro-angiogenic factors, whereas production of anti-angiogenic factors by these cells is hardly affected.

Cuvinte cheie: tumor-associated macrophages, angiogenesis, cancer, glucocorticoids