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Reduced diversity of the human erythrocyte membrane sialic acids in polycythemia vera and absence of N-glycolylneuraminic acid

Domenii publicaţii > Biologie + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: Bratosin D., Palii C., Moicean A. D., Zanetta J-P, Montreuil J.,

Editorial: Elsevier, Biochimie, 88,, p.11,, 2006.

Rezumat:

Sialic acids from the erythrocyte (RBC) membrane of a patient suffering from polycythemia vera, a malignant orphan disorder of hematopoietic
cells, was studied using GC/MS. We found that the sialic acid diversity of these membranes was drastically reduced since only four
entities were identified: Neu5Ac (91.5%) and its 1,7 lactone Neu5Ac1,7L (7.5%) which is absent in normal RBC, Neu4,5Ac2 (0.50%) and
Neu4,5Ac2 9Lt (0.50%); in normal RBC, Neu5,7Ac2, Neu5,9Ac2, Neu5Ac9Lt, Neu5Ac8S and Neu, as well as traces of Kdn, were also present.
Neu5Gc and its O-alkylated or O-acetylated derivatives, which are considered by various authors as cancer markers, were not detected.

Cuvinte cheie: Sialic acid; Red blood cell; Polycythemia vera; N-Glycolylneuraminic acid; N-Acetylneuraminic acid 1,7 lactone // Sialic acid; Red blood cell; Polycythemia vera; N-Glycolylneuraminic acid; N-Acetylneuraminic acid 1,7 lactone