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Novel application of Deuterium MRS: in vivo monitoring of glucose consumption

Domenii publicaţii > Ştiinţe medicale + Tipuri publicaţii > Articol în volumul unei conferinţe

Autori: A. Ye, J.L. Duerk, C.A. Flask and G.D. Mateescu

Editorial: Proceedings 17th Meeting of ISMRM, Honolulu, 2009.

Rezumat:

Deuterium imaging and spectroscopy with ingested /injected D2O bolus were published from the beginnings of MRI [1]. We report here preliminary results of a novel application of deuterium MR (DMR), namely in vivo and ex vivo monitoring of glucose consumption via measurement of nascent mitochondrial water after injection or ingestion of deuteriated glucose (cf. Figure 1). This work is motivated by the need to “see both sides of the coin” of mitochondrial function, namely the oxygen respiration and the glucose metabolic pathways that converge into the final, highly exergonic reaction of water formation. One can thus measure not only glucose, but also oxygen consumption without necessarily employing O-17 enriched air. Besides its immediate bio-analytical value, a long term aim of this project is to test consequences of the targeted deuterium isotope effect on enzymatic processes in healthy and diseased cells and to verify the hypothesis that this effect may be employed for treatment and monitoring of mitochondrial diseases [2].

Cuvinte cheie: Mitocondrion, Deuterium, O-17, Rezonanta Magnetica // Mitocondria, Deuterium, O-17, magnetic Resonance

URL: http://www.case.edu/artsci/chem/faculty/mateescu/