Inscriere cercetatori

Site nou !

Daca nu va puteti recupera parola (sau aveti alte probleme), scrieti-ne la pagina de contact. Situl vechi se gaseste la adresa old.ad-astra.ro

Facebook

Kinetic laws, phase-phase expansions, renormalization group, and INR calibration.

Domenii publicaţii > Ştiinţe medicale + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: Vlad MO, Corlan AD, Morán F, Spang R, Oefner P, Ross J.

Editorial: Proc Natl Acad Sci U S A. , 106, p.6465-70, 2009.

Rezumat:

We introduce systematic approaches to chemical kinetics based on the use of phase-phase (log-log) representations of the rate equations. For slow processes, we obtain a corrected form of the mass-action law, where the concentrations are replaced by kinetic activities. For fast reactions, delay expressions are derived. The phase-phase expansion is, in general, applicable to kinetic and transport processes. A mechanism is introduced for the occurrence of a generalized mass-action law as a result of self-similar recycling. We show that our self-similar recycling model applied to prothrombin assays reproduces the empirical equations for the International Normalized Ratio calibration (INR), as well as the Watala, Golanski, and Kardas relation (WGK) for the dependence of the INR on the concentrations of coagulation factors. Conversely, the experimental calibration equation for the INR, combined with the experimental WGK relation, without the use of theoretical models, leads to a generalized mass-action type kinetic law.

Cuvinte cheie: legi de putere, retele de reactii chimice, calibrare INR, anticoagulare orala // power laws, reaction networks, oral anticoagulants

URL: http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=19366671&db=pubmed&url=http://www.pnas.org/cgi/pmidlookup?view=long&pmid=19366671