Autori: Moldovan GL, D’Andrea AD
Editorial: Cell, 139, p.1222-1224, 2009.
Left unrepaired, DNA interstrand crosslinks represent impassable hurdles for DNA replication, and their removal is a complicated stepwise process involving a variety of enzymes. In a recent paper in Science, Knipscheer et al. (2009) demonstrate that the Fanconi Anemia protein FANCD2 promotes multiple steps of the crosslink repair process.
Cuvinte cheie: DNA repair, Fanconi Anemia, DNA replication, cell cycle regulation, cancer