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Biological effect and the toxicity mechanisms of some dinitrophenyl ethers

Domenii publicaţii > Chimie + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: Dumitras-Hutanu, C. A., Pui, A., Jurcoane, S., Rusu, E., Drochioiu, G

Editorial: Roum. Biotechnol. Lett., 14(6), p.4893-4899, 2009.

Rezumat:

It is assumed that dinitrophenols hinder the proton translocation through the mitochondrial inner membrane, inhibiting thus the oxidative phosphorylation. However, the toxicity mechanism of these uncouplers is still unclear, because the corresponding dinitrophenyl ethers retain the uncoupling behaviors. Therefore, we have investigated the biological effect of 2,4-dinitrophenetole (DNF), dinitroanisole (DNAN), and 3-(2,4-dinitrophenoxy)-propane-1,2-diol (DNG) in wheat experiments as compared to that of classical dinitrophenols. The biological effect of all these dinitrophenyl derivatives was effective even at very low concentration. Part of their toxicity seems to be related to the solubility of the investigated compounds. Contrary to the current theories, the toxicity induced by the investigated dinitrophenyl ethers was not related to the corresponding dinitrophenols obtained by hydrolysis. Besides, both the dinitrophenyl ethers and the other uncoupling agents are characterized by a significant absorbance in IR at about 6000 cm-1, corresponding to an energy quantum similar to that of ATP molecule. Consequently, a hypothetically alternative mechanism of toxicity based on spectral measurements was introduced.

Cuvinte cheie: dinitrophenyl ethers, dinitrophenetole, dinitroanisole, FT-IR, toxicity mechanism, wheat germination