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Nanostructured poly(3,4-ethylenedioxythiophene)–metalloporphyrin films: Improved catalytic detection of peroxynitrite

Domenii publicaţii > Chimie + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: S.F. Peteu et al

Editorial: Biosensors & Bioelectronics, in press, 2010.


We investigated in this paper the sensing performance of inherently conductive polymer, poly(3,4-ethylenedioxythiophene) (PEDOT), functionalized with hemin (iron protoporphyrin) as an electrocatalytic
reporter. The sensing platform is prepared by electrodeposition of a composite film of hemin–PEDOT on a 30-m diameter carbon fiber electrode (CFE). The polymerized films were characterized by field emission scanning electron microscopy (FESEM), which pointed to nanostructured films
with tortuous pores. The electro-catalytic oxidation of peroxynitrite was characterized by cyclic voltammetry
as well as other electrochemical methods. The catalytic current is proportional to the analyte’s
concentration. Optimized hemin–PEDOT modified CFEs were utilized for the first time to detect ONO2-, with a response time down to 5 s and a limit of detection as low as 200nM as evidenced by amperometry.
Our hemin–PEDOT modified CFEs have a sensitivity of 13 nA/M, ca.130 times higher than the bare CFE.
More work is underway using other metalloporphyrins as electrocalalysts to improve the detection limit, the selectivity, and to further miniaturize these hemin–PEDOT modified electrodes.
©2010 Elsevier B.V. All rights reserved.

Cuvinte cheie: Peroxynitrite, Nano, Biosensors, Polyethylenedioxythiophene (PEDOT) // Peroxynitrite, Nano, Biosensors, Polyethylenedioxythiophene (PEDOT)