Autori: Negreanu LM, Assor P, Mateescu B, Cirstoiu C.
Editorial: World J Gastroenterol. 2008 Nov 7;14(41):6285-8., 2008.
Alterations of normal function of interstitial cells of Cajal (ICC) are reported in many intestinal disorders. Diagnosis of their involvement is rare (infrequent), but necessary to propose a specific treatment. This article reviews the place of ICC in the pathogenesis of achalasia, gastroesophageal reflux disease, infantile hypertrophic pyloric stenosis, chronic intestinal pseudo-obstruction and slow transit constipation. Moreover we discuss the role of the Cajal cells in the development of stromal tumors of the gastrointestinal tract.
Cuvinte cheie: Cajal cells; c-kit; Intestinal motility; Achalasia; Gastrointestinal stromal tumor