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Stimulation of wound healing by helium atmospheric pressure plasma treatment

Domenii publicaţii > Fizica + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: Andrei Vasile Nastuta, Ionut Topala, Constantin Grigoras, Valentin Pohoata and Gheorghe Popa

Editorial: IOP Science, Journal of Physics D: Applied Physics, Volume 44, Number 10, 105204, 2011.

Rezumat:

New experiments using atmospheric pressure plasma have found large application in treatment of living cells or tissues, wound healing, cancerous cell apoptosis, blood coagulation on wounds, bone tissue modification, sterilization and decontamination. In this study an atmospheric pressure plasma jet generated using a cylindrical dielectric-barrier discharge was applied for treatment of burned wounds on Wistar rats’ skin. The low temperature plasma jet works in helium and is driven by high voltage pulses. Oxygen and nitrogen based impurities are identified in the jet by emission spectroscopy. This paper analyses the natural epithelization of the rats’ skin wounds and two methods of assisted epithelization, a classical one using polyurethane wound dressing and a new one using daily atmospheric pressure plasma treatment of wounds. Systemic and local medical data, such as haematological, biochemical and histological parameters, were monitored during entire period of study. Increased oxidative stress was observed for plasma treated wound. This result can be related to the presence in the plasma volume of active species, such as O and OH radicals. Both methods, wound dressing and plasma-assisted epithelization, provided positive medical results related to the recovery process of burned wounds. The dynamics of the skin regeneration process was modified: the epidermis re-epitelization was accelerated, while the recovery of superficial dermis was slowed down.

Cuvinte cheie: plasma la presiune atmosferica de tip jet, vindecarea ranilor // atmospheric pressure plasma jet, wound healing

URL: http://iopscience.iop.org/0022-3727/44/10/105204