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Safety studies for the antibiotic Unifenicol 10% in broilers

Domenii publicaţii > Ştiinţe medicale + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: Alexandra Trif, Cristina R. T., Muselin F., Eugenia Dumitrescu, Morar D., Catana N., Diana Argherie

Editorial: Veterinary Clinical Pathology, ISSN 0275-6383, 33, 4, p.265, 2004.

Rezumat:

Introduction: Unifenicol 10% is an antibiotic (florfenicol a.i.) produced by United Animal Health Ltd. Budapest, Hungary, with a known intense antibacterial activity recommended in broilers against Chlamydia spp., Escherichia coli, Pasterurella spp. and Mycoplasma. The aim of the study was to assess the cosequences of the therapeutic dose (TD), 1 ml Unifenicol 10%/litre drinking water, double TD (TD x 2), three and five times TD (TD x 3, TD x 5) upon some bioproductive and health parameters in broilers.
Materials and Methods: The study was carried out along five days (recommended therapy period) on 5 groups (4 experimental – E and one control – C), 10 individuals each – Cobb 500 hybrid broilers, one week old, as follows: E1: TD; E2: TD x 2; E3: TD x 3; E4: TD x 5; C = no treatment. Water and fodder consumptions, daily weight gain were measured. Erythrocytes (E), leukocytes (L) count, haemoglobin (Hb.), haematocrit (Ht.) values, leucograme (LK) were determined by automatic MS-9VET analyzer and total plasmatic protein (P), albumin (A), globulin (G), uric acid (Ua), creatinine (C); GOT, GPT, ALP enzymes by VET SCREEN analyzer. Local and general tolerance was evaluated. After euthanasia, followed post-mortem assessment and microscopic examination (Haematoxylin-Eosin stain).
Results: The investigations pointed out a good local and general tolerance in E1 and E2 groups but diarrhoea in E3 and E4 groups. Comparative to C group was registered a limited decrease of appetite for fodder (more evident in E3: -22.82%) and water (more evident in E3: -8.02% and E4: -28.86%) and of daily weight gain (aprox. -23.16% in E2, E3 and E4); no significant (p>0.05) and in physiological range dynamics of E, L, Ht., Hb., low amplitude fluctuation of plasmatic P, A, G, not related to dose and in physiological limits; creatinin increase (p>0.05) only in E3 (+28.57%) and E4 (+42.85%) groups, but in physiological limits; decrease of Ua significant (p = 0.05) for E1 (-69%), E2 (-34,37%), E3 (-50%) groups, but not in E4 (-25.62%), the values being lower than the physiological limits; progressive limited not significant (p>0.05), relate to dose increase of GOT (E1: +6.55%, E2: +9.28%, E3: +14.2%) and pronounced significant (p = 0.05) in E4 group of GPT (+118.18%); decrease of ALP concentration, significant (p>0.05) in E1 (-27.02%), E2 (-31.96%), not significant (p>0.05) in E3 (-12.33%) and not significant increase in E4 (+1.19%). The assessment of post-mortem state and microscopic examination showed: slight liver enlargement, diffuse hepatic degeneration, liver nuclear heterochromatinization, vacuolar degeneration, slight degeneration signs in nephrons and renal corpuscles, slight spleen enlargement, distension and gaseous, respectively brownish foamous content in caecums in individuals from E3 and E4 groups.
Conclusion: Unifenicol 10%, in the framework of the studied parameters, has no registrable adverse effects in broilers at doses until three times higher than the TD was.

Cuvinte cheie: florfenicol, siguranta, pui carne // florfenicole, safety, broilers

URL: http://onlinelibrary.wiley.com/doi/10.1111/j.1939-165X.2004.tb00385.x/abstract