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Photodegradation of inclusion complexes of naproxen and niflumic acid with beta-cyclodextrin

Domenii publicaţii > Fizica + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: M. Bogdan, C. Floare, Diana Bogdan, S.I. Farcas

Editorial: STUDIA Universitatis Babes-Bolyai, Physica, L(4), p.721-724, 2005.

Rezumat:

The paper presents results of the studies on photochemical stability of naproxen (NAP) and niflumic acid (NIF) in their liquid inclusion complexes with β-cyclodextrin (β-CD). The process of photodegradation was studied by UV spectrophotometry. Quantitative evaluation of the photochemical decomposition was performed on the basis of the calculated rate constant, k0, for the pure drug, k, the photodegradation rate constant of the drug in the inclusion complex and the stability constant K of the complex.

Cuvinte cheie: beta-cyclodextrin, naproxen, niflumic acid, inclusion complexes

URL: http://www.itim-cj.ro/~cfloare/publ/photodegradation.pdf