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The value of the ultrastructural pattern of myeloperoxidase and plateletperoxidase in identification of two blastic cell types during transformation of a chronic myeloproliferative disorder

Domenii publicaţii > Ştiinţe medicale + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: Moldoveanu E, Moicean A, Colita A, Halalau F

Editorial: HAEMATOLOGIA, 27(3), p.135-141, 1996.

Rezumat:

The value of the ultrastructural pattern of myeloperoxidase (MPO) and plateletperoxidase (PPO) staining is evaluated for the identification of the type of blastic cells during the acute transformation of a chronic myeloproliferative disorder. MPO and PPO are generally accepted as lineage specific markers for the detection of myeloid or megakaryocytic differentiation of the blast cells. The ultrastructural pattern of myeloperoxidase (MPO) and plateletperoxidase (PPO) permitted us to identify two types of blastic cells (one from the myeloid and the other from the megakaryoblastic lineage) in the acute transformation of a chronic myeloproliferative disorders.

Cuvinte cheie: chronic myeloproliferative disorders (cMPDs); myeloperoxidase (MPO); plateletperoxidase (PPO); megakaryocyte; megakaryoblast; promyelocyte