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Hydractinia echinata test system. II. SAR toxicity study of some anilide derivatives of Naphthol-AS type

Domenii publicaţii > Chimie + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: Chicu, Sergiu Adrian; Funar-Timofei, Simona; Simu, Georgeta-Maria

Editorial: 82 (11), p.1578-1582, 2011.


In this paper, a toxicity study for a series of anilides of Naphthol-AS type is presented. The toxicity of the model compounds was determined by using the Hydractinia echinata (Hydrozoa) test system. Conformational analysis of Naphthol-AS derivatives was performed to elucidate the possible enzymatic hydrolysis mechanism of these compounds. This mechanism occurs with different rates and always leads to a stoichiometric mixture of reaction products, consisting in the substituted amine and the corresponding α-hydroxy-carboxylic acid. With one exception, the toxicities of the reaction products are subadditive. Quite similar measured toxicity values, log(1/MRC50), led to their average calculated values, and thus to the establishment of class isotoxicity. This method represents a practical alternative useful for the reduction of experimental tests on animals to the lowest possible level, in accordance to the ‘3Rs’ (reduction, refinement and replacement) concept.

Cuvinte cheie: Hydractinia echinata; Naphthol-AS; Class isotoxicity; Omega software; Conformational analysis