Autori: Coculescu M, Pavel S

Editorial: Endocrine Society, USA, Journal of Clinical Endocrinology and Metabolism, 36(5), p.1031-1032, 1973.

Rezumat:

M. COCULESCU and S. PAVEL
Institute of Endocrinology Bucharest, Rumania
Abstract
Cerebrospinal fluid (CSF) from patients with idiopathic diabetes insipidus (DI) contains an active principle with antidiuretic, hen oviduct and frog bladder activities. Tryptic digestion of the biological activities suggests that the active principle is a peptide containing at least one basic amino acid. The biological activities of CSF from DI patients differ significantly from those of arginine vasopressin (AVP) and oxytocin, but are not significantly different from those of arginine vasotocin (AVT). No such biological activities could be detected in the CSF of normal subjects of the same age and sex.

Received December 18, 1972.
Copyright © 1973 by The Endocrine Society

Abstract
Cerebrospinal fluid (CSF) from patients with idiopathic diabetes insipidus (DI) contains an active principle with antidiuretic, hen oviduct and frog bladder activities. Tryptic digestion of the biological activities suggests that the active principle is a peptide containing at least one basic amino acid. The biological activities of CSF from DI patients differ significantly from those of arginine vasopressin (AVP) and oxytocin, but are not significantly different from those of arginine vasotocin (AVT). No such biological activities could be detected in the CSF of normal subjects of the same age and sex.

Received December 18, 1972.
Copyright © 1973 by The Endocrine Society
doi: 10.1210/jcem-36-5-1031

Cuvinte cheie: vasotocina,activitate antidiuretica, lichidul cefalorahidian,diabetul insipid uman // vasotocin,antidiuretic activity,cerebrospinal fluid, human diabetes insipidus

URL: http://jcem.endojournals.org/content/36/5/1031.full.pdf+html