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Noncovalent immobilization of collagen on the surface of silanized hydroxyapatite

Domenii publicaţii > Chimie + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: M. Olaru, B. C. Simionescu, C. Cotofana, X. Patras

Editorial: OAM-RC, 2(11), p.726-729, 2008.

Rezumat:

The aim of this study was to synthesize and characterize a hybrid composite based on type I hydrated collagen, hydroxyapatite and a silane precursor (amino-propyltriethoxysilane). Through sol-gel approach of the precursor and noncovalent immobilization of collagen on the surface of hydroxyapatite, a new type of hybrid material was obtained in which microspheres comprising silica and hydroxyapatite particles are dispersed in an oriented fibrous network of collagen fibrils. Moreover, the sol-gel reactions between the above-mentioned components were not accompanied by conformational changes of the adsorbed collagen, thus preserving its secondary structure.

Cuvinte cheie: collagen, hydroxyapatite, sol gel