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Biocompatible and bioactive nanostructured glass coatings synthesized by pulsed laser deposition: In vitro biological tests

Domenii publicaţii > Fizica + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: A.C. Popescu, F. Sima, L. Duta, C. Popescu, I.N. Mihailescu, D. Capitanu, R. Mustata, L.E. Sima, S.M. Petrescu, D. Janackovic

Editorial: Applied Surface Science, 255, p.5486–5490, 2009.

Rezumat:

We report on the synthesis by pulsed laser deposition with a KrF* excimer laser source (l = 248 nm,
t = 25 ns) of bioglass thin films of 6P57 and 6P61 types. Physiology, viability, and proliferation of human
osteoblast cells were determined by quantitative in vitro tests performed by flow cytometry on primary
osteoblasts cultured on pulsed laser deposited bioglasses. Both types of glass films proved to be
appropriate mediums for cell survival and proliferation. In a parallel investigation, cell morphology and
adhesion to the surface was studied by fluorescence microscopy and scanning electron microscopy.
Strong bonds between the materials and cells were found in both cases, as osteoblast pseudopodes
penetrated deep into the material. According to our observations, the 6P57 glass films were superior with
respect to viability and proliferation performances.

Cuvinte cheie: Bioglass thin films, In vitro biotests, Pulsed laser deposition

URL: http://lspi.inflpr.ro/