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From pluripotent stem cells to multifunctional cordocytic phenotypes in the human brain: an ultrastructural study

Domenii publicaţii > Ştiinţe medicale + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: Viorel Pais, Leon Danaila, Emil Pais

Editorial: Ultrastructural Pathology, 36(4), p.252-259, 2012.


Light microscopy and transmission electron microscopy were used to investigate surgical cases in a variety of pathological conditions (thromboses, tumors, cerebrovascular malformations, Moyamoya disease) to identify and characterize different phenotypes belonging to a new interstitial cell recently described ultrastructurally in the brain and here named „cordocyte.” Also, this work is an attempt to identify and characterize precursor/stem cells for cordocytic lineage in the perivascular areas, within perivascular nerves and pia mater (now considered a cordocytic-vascular tissue). Unexpected relationships and functions emerge from observations concerning these phenotypes, almost ubiquitous, but not yet fully studied in the brain.

Cuvinte cheie: Cordocytic phenotypes, roles, stem cells, ultrastructure, vessels