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The promise of EPC-based therapies on vascular dysfunction in diabetes.

Domenii publicaţii > Biologie + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: A. Georgescu, N. Alexandru, A. Constantinescu, I. Titorencu, D. Popov

Editorial: European Journal of Pharmacology, 669, p.1–6, 2011.

Rezumat:

Diabetes mellitus is one of the most common metabolic diseases in the world and the vascular dysfunction
represents a challenging clinical problem. In diabetes, endothelial cells (ECs), lining the inner wall of blood
vessels, do not function properly and contribute to impaired vascular function. Circulating endothelial
progenitor cells (EPCs), the precursor of mature EC, actively participate in endothelial repair, by moving to the
vascular injury site to form mature EC and new blood vessels. Knowing that the therapeutic interventions can
improve only a part of EC dysfunction in diabetes, this review addresses recent findings on the use of EPCs for
cell therapy. The strategies proposed in review are based on in vivo and in vitro studies and, thus, their
physiological relevance is confirmed. EPC therapy shows great promise for the prevention and cure of
diabetes-induced vascular dysfunction.

Cuvinte cheie: diabetes, endothelial progenitor cells, strategies