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PVA-based hybrid composites with luminescent properties for drug delivery

Domenii publicaţii > Chimie + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: Bogdan C. Simionescu, Mihaela Olaru, Irina Bordianu, Cristian Ursu, Corneliu Cotofana

Editorial: High Performance Polymers, 24(6), p.449–459, 2012.

Rezumat:

The aim of this study was to synthesize and characterize new poly(vinyl alcohol)s (PVAs) hybrid composites with or
without a basic drug content, e.g., 2-[4-(2-methylpropyl)phenyl]propanoic acid (ibuprofen), obtained at different pH
values. Through sol-gel approach of chloropropyltriethoxysilane with a PVA precursor containing a fluorescent dye (lissamine
rhodamine-B sulfonyl chloride), new hybrid materials with porous structures were obtained. Due to encapsulation
in a porous network, the influence of rhodamine H-dimers on fluorescence quenching was negligible and the presence of
free dye was exploited as a mechanism for anchoring the ibuprofen molecules through hydrogen bonding onto pore
surfaces.

Cuvinte cheie: poly(vinyl alcohol), ibuprofen, fluorescent dye, sol-gel technique, porous composites