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A comparative study concerning the chromatographic behaviour and lipophilicity of certain natural toxins

Domenii publicaţii > Chimie + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: Rodica Domnica Nascu-Briciu, Costel Sarbu

Editorial: Journal of Separation Science, 35, p.1059-1067, 2012.

Rezumat:

The characterization and classification of some natural toxins (mycotoxins and alkaloids) is established by high-performance thin-layer chromatography (HPTLC) using chemically bonded stationary phases of RP-18, RP-18W, RP-8, RP-2, RP-NH2, RP-CN and RP-Diol. The used mobile phases are mixtures of methanol–water in different proportions of volume, chosen to create a suitable migration during the chromatographic process. The lipophilicity is described through different chromatographic descriptors, such as RM0, mean of RM (mRM), and scores of RM values corresponding to the first principal component (PC1/RM). The investigated compounds are characterized also by a series of computed lipophilicity descriptors (logP and logD values). The chromatographic behaviour of toxins is evidenced by graphical profiles of the lipophilicity descriptors. In addition, scores and loadings resulting from covariance matrix of retention data enable new information about similarity and differences observed between the investigated compounds. The experimental lipophilicity indices estimated from retention data are directly correlated with the computed values, via computer software and Internet module, at a high significant statistical level.

Cuvinte cheie: Chemically bonded phases;Lipophilicity;Natural toxins;PCA

URL: http://onlinelibrary.wiley.com/doi/10.1002/jssc.201200050/abstract