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Adult leptomeningeal cerebellar heterotopia in contact with the posterior inferior cerebellar artery

Domenii publicaţii > Ştiinţe medicale + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: Rusu MC

Editorial: Anat Sci Int, 2012.


A leptomeningeal mass was encountered during microdissection of a 63-year-old male cadaver, located dorsal to the left side of the medulla oblongata. The structure was compressing the posterior inferior cerebellar artery (PICA) and was composed of cerebellar-like tissue. Immunohistochemistry for S100 protein, glial fibrillary acidic protein and neurofilaments (NF, the triplet proteins and the 200 kD antibody) on paraffin-embedded samples confirmed the cerebellar heterotopion. Abundant Lewy-like degenerative bodies were also identified within the heterotopion; they were positive for the NF triplet and negative for the 200 kD neurofilaments. Purkinje cells were rare. This is the first evidence of a leptomeningeal cerebellar heterotopia in contact with PICA in adult. Such subtentorial heterotopias, even if rare, should be searched for during clinical, paraclinical and surgical explorations of the posterior fossa.

Cuvinte cheie: cerebellum; Lewy-like bodies; immunohistochemistry; posterior inferior cerebellar artery