Scopul nostru este sprijinirea şi promovarea cercetării ştiinţifice şi facilitarea comunicării între cercetătorii români din întreaga lume.
Autori: Simona Cîntã-Pînzaru, Cristina A Dehelean, Codruta Soica, Monica Culea and Florin Borcan
Editorial: Chemistry Central Journal, 6(67), 2012.
We employed vibrational FT-IR and FT-Raman spectroscopy as rapid, sensitive and efficient techniques for qualitative and semi-quantitative analysis of the pentacyclic triterpene based natural products as highly effective anticancer agents obtained from the Betula pendula Roth birch bark. Nine bark samples from the abundant forest flora of Apuseni Mountains, Romania were Raman evaluated concerning their triterpenes content. Additionally, three different extraction conditions have been applied for one birch bark specimen aiming to obtain the highest triterpene content in the extraction product. Methanol solvent and longer extraction time revealed the product with highest triterpene content as revealed by the vibrational analysis. The conclusions were supported by the GC-MS analysis that revealed two major compounds, betulin (59%) and lupeol (41%) in the highest purity extract.
Cuvinte cheie: Natural extracts; Betulin; Betulinic acid; Lupeol; FT-Raman; FT-IR