Autori: Radu BM, Bramanti P, Osculati F, Flonta ML, Radu M, Bertini G, Fabene PF
Editorial: Mediators of Inflammation, 2013; Article ID: 648268, p.18 pages, 2013.
Chronic pain is a debilitating condition with major socio-economical impact, whose neurobiological basis is still not clear. An involvement of the neurovascular unit (NVU) has been recently proposed. In particular, the blood brain barrier (BBB) and blood spinal cord barrier (BSCB), two NVU key players, may be affected during the development of chronic pain; in particular, transient permeabilization of the barrier is suggested by several inflammatory- and nerve injury-based pain models, and we argue that the clarification of molecular BBB/BSCB permeabilization events will shed new light in understanding chronic pain mechanisms. Possible biases in experiments supporting this theory and its translational potentials are discussed. Moving beyond an exclusive focus on the role of the endothelium, we propose that our understanding of the mechanisms subserving chronic pain will benefit from the extension of research efforts to the NVU as a whole. In this view, the available evidence on the interaction between analgesic drugs and the NVU is here reviewed. Chronic pain comorbities, such as neuroinflammatory and neurodegenerative diseases, are also discussed in the view of NVU changes, together with innovative pharmacological solutions targeting NVU components in chronic pain treatment.
Cuvinte cheie: Neurovascular unit, chronic pain, blood brain barrier, blood spinal cord barrier, neurodegenerative diseases, comorbidity, ABC-transporters