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Dynamics of female sexual hormones after twelve month sex eposure to lead acetate

Domenii publicaţii > Ştiinţe medicale + Tipuri publicaţii > Articol în volumul unei conferinţe

Autori: Eugenia Dumitrescu, Florin Muselin, Ioan Macinic, Alexandra Trif, Cristinan Florin Lazarescu, Crina Laura Mosneang, Romeo Teodor Cristina

Editorial: Current Opinion in Biotechnology , 24 , p.S104, 2013.

Rezumat:

The aim of the study was to evaluate lead reproductive toxicity. The
study was carried out on 28 white Wistar adult female rats exposed
to lead acetate for twelve months, divided in three experimental (E)
groups, exposed to 50 ppb Pb (E1), 100 ppb Pb (E2), 150 ppb Pb (E3)
and one control (C) group which received tap water not containing
lead. The female rats were fed with standard diets, corresponding to
species and age. Forages and water were ad libitum. Blood samples
were drawn from females in proestrus state for FSH, LH, estradiol,
and progesterone and, also testosterone level by ELISA technique.
Exposure to lead acetate determined: significant (P < 0.01) decrease of serum FSH level comparative to C group and inversely, significantly (P < 0.01) correlated with the exposure level; significant (P < 0.01) higher serum LH level comparative to C group and directly, significantly (P < 0.01) correlated with the exposure level; significant (P < 0.01) decrease of the estradiol serum level comparative to C group, inversely, significantly (P < 0.01) correlated with the exposure level; significant (P < 0.01) decrease of serum progesterone level comparative to C group, inversely, significantly (P < 0.01) correlated with the exposure level; significant (P < 0.01) higher serum testosterone level comparative to C group, in direct, significant correlation with the exposure level.

Cuvinte cheie: rat females, sexual hormones, lead acetate, exposure