Scopul nostru este sprijinirea şi promovarea cercetării ştiinţifice şi facilitarea comunicării între cercetătorii români din întreaga lume.
Autori: Frunza, I., Trif, A., Brezovan, D., Carpinisan, L., Ghise, A., Doma, A. O., ... & Savici, J.
Editorial: Current Opinion in Biotechnology, 24, p.S104, 2013.
Chromium exists in several oxidation states but trivalent and
hexavalent are the most common ones. Hexavalent chromium is
manmade and is 100–1000 times more toxic than trivalent form.
Chromium is used in the production of chromates, chromium plating,
chromate pigment manufacture, the production of cement and
stainless steel. The aim of this study was the evaluation of body,
genital organs (testes, epididymis) and sexual accessory glands
weight (seminal vesicles, prostate, bulbo-urethral glands) at sexual
maturity after hexavalent chromium exposure of male rats in prepubertal
period. The study was carried out on 28 white Wistar male
pup rats divided in four groups and exposed to potassium dichromate
via drinking water, as follows: E1 25ppm Cr VI; E2 50ppm
Cr VI; E3 75ppm Cr VI; control tap water. The rats were exposed
from weaning until sexual maturity when, they were sacrificed following
protocols and ethical procedures (Ketamine and Xylazine)
and genital organs and sexual accessory glands were dissected out,
trimmed of attached tissues and weighted using analytical balance
ShimadzuAY220. The results were statistically analyzed byANOVA
method and Student test.
The study pointed out: significant decrease of body weight comparative
to control group and in inverse, significant, correlation to
exposure level; decrease of all sexual organs weight comparative to
control group, not significant only for epididymis E1 group, and in
inverse, significant correlation to exposure level. The results of our
study confirm that hexavalent chromium is toxicant which affects
negatively body and sexual organs weight.
Cuvinte cheie: rats, male, weight, sexual organs, potassium dichromate