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Is lung a target of diabetic injury? The novel Pros and Cons evidences

Domenii publicaţii > Biologie + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: Doina Popov

Editorial: The Publishing House of the Romanian Academy, Proc. Rom. Acad., Series B, V(15), p.99–104, 2013.

Rezumat:

The rationale for questioning whether lung is/ or is not affected by diabetes is based on two reasons: the frequent dysfunction of the lung encountered at the newborn children of diabetic mothers and the need to understand the pathophysiology of this organ for anti-diabetics administration by inhalation.
This review attempts to give an answer to the above dilemma, based on the most recent results. With this aim, Medline and PubMed data bases have been searched for the interval 2009-2013 (terms: lung,
diabetes mellitus). The search showed that diabetic lung is the site of microangiopathic changes; the functional parameters decline, the oxidative and inflammatory stress is installed, while the antioxidant defense is diminished. The consequence of diabetes-induced lung modifications is the increased risk
for obstructive, inflammatory, and infectious diseases. In obesity, “the fatty diabetic lung” is subjected to the additional harmful effects of lipotoxicity. Meanwhile, few authors claim that the vascular and ventilation reserves may compensate for diabetes-induced lung dysfunction.Examination of balance between the Pros and Cons evidences shows that it tilts towards the Pros side,as justified by the prominent modifications occurring in diabetic lung, which eventually conduct to alterations in gas exchange.

Cuvinte cheie: microangiopatie, obezitate, hipertensiune, insulina, surfactant pulmonar // microangiopathy, obesity, hypertension, insulin, pulmonary surfactant.

URL: www.ear.ro