Due to their special and growing medical recent interest, the fullerenes started to be a very studied class of chemical compounds. In order to improve their water solubility and to reduce their cytotoxic characteristics, the fullerenes have been coupled in a system fullerene/PVP/porphyrin (C60/PVP/TPP) and its application in photodynamic therapy will be evaluated in this paper. The oxidative stress effects on photodynamic therapy with systems fullerene/poly-N-vinylpirrolidone/5,10,15,20-tetrakis(4-phenyl)porphyrin