Tag archive of aqueous antidote solution

HPLC METHOD FOR THE SIMULTANEOUS DETERMINATION OF THE COMPONENTS OF AN AQUEOUS SOLUTION ANTIDOTE

Abstract The objectives of this study were to develop and validate a method for the simultaneous HPLC-UV determination of obidoxime (OBI), scopolamine (SCA), Atropine (ATR) and imipramine (I) in an aqueous antidote solution. An ion-pair mechanism with DAD (diode array detector) detection was used to quantitatively determine the four drugs. The proposed HPLC method uses a Kromasil 100-5C8 (250x4.6mm) column, gradient elution, at 25°C column temperature.

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