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Tudor Oprea

Tudor Oprea

* Bacalaureat, chimie industriala, 1983, Timisoara
* Doctor-medic, medicina generala, 1990, Timisoara
* Doctor in stiinte medicale, 1992, Timisoara (cu Francisc Schneider)
* Visiting Scientist, Univ Utrecht (Olanda), 1990-1991
* Post-doc, Washington University St. Louis, 1992-1994 (cu Garland Marshall)
* Post-doc, Los Alamos National Laboratory, 1994-1996 (cu Angel Garcia)
* Research Scientist (1996-2000), apoi Associate Director, Enabling Science and Technologies (2000-2002), AstraZeneca R&D, Suedia
* Profesor, Univ Vest Timisoara (1999-2003), part-time
* Profesor, Univ of New Mexico, Dept of Biochemistry and Molecular Biology, 2002-2012 (Chief, Division of Biocomputing)
* Profesor, Univ of New Mexico, Dept of Internal Medicine, 2012-prezent (Chief, Translational Informatics Division)

* detalii suplimentare: http://datascience.unm.edu
* profil Google Scholar: https://scholar.google.com/citations?hl=en&user=2O0vLx8AAAAJ
* profil LinkedIn: https://www.linkedin.com/in/tudorioprea

University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.

E-mail: trimite un mesaj.

Pagina web a instituţiei: http://datascience.unm.edu/
Pagina web personala: http://datascience.unm.edu

Urmareste linkul ResearcherID pentru toate articolele cercetatorului: A-5746-2011. Tabelul detaliat al articolelor este in josul paginii.

Nascut(a) in: 1965

Interese: Informatica, Modelare Moleculara, QSAR, Descoperirea Medicamentelor, Machine Learning, Health Informatics

flag Detalii:
Interesat in descoperirea medicamentelor, folosind informatica medicala, chimica si bioinformatica. Expert in informatica medicamentului, reprofilare de medicamente, si screening virtual. In prezent lucrez la prioritizarea de tinte pentru medicamente (targetcentral.ws). Vezi si versiunea in limba engleza.

flag Details:
Health informatics scientist with interests in knowledge management applied to lead and drug discovery, target and drug repurposing, translational informatics and health-record analytics. I contributed to conceptual developments for lead-likeness, systems chemical biology, and the identification of selective, potent compounds for the G-protein estrogen receptor, the formyl peptide receptors FPR1 and FPR2, the Rac1 and Cdc42 GTP-ases, and GLUT5, a fructose-only transporter. My work led to clinical trials for Raltegravir and Ketorolac, both evaluated as anti-cancer agents. I serve as PI for the NIH project "Illuminating the Druggable Genome Knowledge Management Center“ (see also http://targetcentral.ws).

Publicații selectate:

* T.I. Oprea, Lead structure searching: Are we looking at the appropriate property?, J. Comput.-Aided Mol. Design, 16, 2002.

* L. Kurunczi, M. Olah, T.I. Oprea, C. Bologa, Z. Simon, MTD-PLS: A PLS-Based Variant of the MTD Method. 2. Mapping Ligand-Receptor Interactions. Enzymatic Acetic Acid Esters Hydrolysis, Journal of Chemical Information and Computer Science, 42, 2002.

* Tudor I Oprea, Chemical space navigation in lead discovery, Current Opinion in Chemical Biology, 6, 2002.

* Zamora, Ismael; Oprea, Tudor I.; Ungell, Anna-Lena, Prediction of oral drug permeability, Prous Science, Barcelona, Spain, Hoeltje, Hans-Dieter; Sippl, Wolfgang, Rational Approaches to Drug Design, Proceedings of the 13th European Symposium on Quantitative Structure-Activity Relationships, 2001.

* Oprea, Tudor I.; Gottfries, Johan, ChemGPS: A chemical space navigation tool, Prous Science, Barcelona, Spain, Hoeltje, Hans-Dieter; Sippl, Wolfgang, Rational Approaches to Drug Design, Proceedings of the 13th European Symposium on Quantitative Structure-Activity Relationships, 2001.

* Oprea, Tudor I.; Zamora, Ismael; Ungell, Anna-Lena, Pharmacokinetically Based Mapping Device for Chemical Space Navigation, Journal of Combinatorial Chemistry, 4, 2002.

* Head, Richard D.; Smythe, Mark L.; Oprea, Tudor I.; Waller, Chris L.; Green, Stuart M.; Marshall, Garland R, VALIDATE: A New Method for the Receptor-Based Prediction of Binding Affinities of Novel Ligands., J. Am. Chem. Soc., 118(16), 1996.

* Oprea, Tudor I.; Garcia, Angel E., Three-dimensional quantitative structure-activity relationships of steroid aromatase inhibitors., J. Comput.-Aided Mol. Des., 10(3), 1996.

* Oprea, Tudor Ionel; Kurunczi, Ludovic; Timofei, Simona, QSAR studies of disperse azo dyes. Towards the negation of the pharmacophore theory of dye-fiber interaction?, Dyes Pigm., 33(1), 1997.

* Waller, Chris L.; Oprea, Tudor I.; Chae, Kun; Park, Hee-Kyoung; Korach, Kenneth S.; Laws, Susan C.; Wiese, Thomas E.; Kelce, William R.; Gray, L. Earl Jr, Ligand-Based Identification of Environmental Estrogens., Chem. Res. Toxicol., 9(8), 1996.

* Tung, C.-S.; Oprea, T. I.; Hummer, G.; Garcia, A. E., Three-dimensional model of a selective theophylline-binding RNA molecule., J. Mol. Recognit., 9(4), 1996.

* Sulea, Traian; Oprea, Tudor Ionel; Muresan, Sorel; Chan, Shek Ling, A different method for steric field evaluation in CoMFA improves model robustness., J. Chem. Inf. Comput. Sci., 37(6), 1997.

* Oprea, Tudor I.; Marshall, Garland R, Receptor-based prediction of binding affinities., Perspect. Drug Discovery Des., 9-11, 1998.

* Oprea, Tudor I., Virtual Screening in Lead Discovery: A Viewpoint, Molecules, 7(1), 2002.

* Sulea, Traian; Kurunczi, Ludovic; Oprea, Tudor I.; Simon, Zeno., MTD-ADJ: a multiconformational minimal topologic difference for determining bioactive conformers using adjusted biological activities., J. Comput.-Aided Mol. Des., 12(2), 1998.

* Oprea, Tudor I.; Hummer, Gerhard; Garcia, Angel E., Identification of a functional water channel in cytochrome P450 enzymes., Proc. Natl. Acad. Sci. U. S. A., 94(6), 1997.

* Teague, Simon J.; Davis, Andrew M.; Leeson, Paul D.; Oprea, Tudor I., The design of leadlike combinatorial libraries., Angew. Chem., Int. Ed., 38(24), 1999.

* Oprea, Tudor I., Property distribution of drug-related chemical databases., J. Comput.-Aided Mol. Des., 14(3), 2000.

* Oprea, T. I.; Gottfries, J., Toward minimalistic modeling of oral drug absorption., Journal of Molecular Graphics & Modelling, 17(5/6), 1999.

* Oprea, T. I.; Gottfries, J.; Sherbukhin, V.; Svensson, P.; Kuhler, T. C., Chemical information management in drug discovery: optimizing the computational and combinatorial chemistry interfaces., J. Mol. Graphics Modell., 18(4/5), 2000.

* Oprea, Tudor I.; Gottfries, Johan., Chemography: The Art of Navigating in Chemical Space., Journal of Combinatorial Chemistry, 3(2), 2001.

* Olsson, Thomas; Oprea, Tudor I., Cheminformatics: a tool for decision-makers in drug discovery., Curr. Opin. Drug Discovery Dev., 4(3), 2001.

* Oprea, Tudor I.; Davis, Andrew M.; Teague, Simon J.; Leeson, Paul D., Is There a Difference between Leads and Drugs? A Historical Perspective., Journal of Chemical Information and Computer Sciences, 41(5), 2001.

* Nilsson, Jonas W.; Thorstensson, Fredrik; Kvarnstroem, Ingemar; Oprea, Tudor I.; Samuelsson, Bertil; Nilsson, Ingemar., Solid-phase synthesis of libraries generated from a 4-phenyl-2-carboxy-piperazine scaffold., Journal of Combinatorial Chemistry, 3(6), 2001.

* Oprea, Tudor I.; Kurunczi, Ludovic; Olah, Marius; Simon, Zeno, MTD-PLS: a PLS-based variant of the MTD method. A 3D-QSAR analysis of receptor affinities for a series of halogenated dibenzoxin and biphenyl derivatives., SAR QSAR Environ. Res., 12(1-2), 2001.

* Oprea, Tudor I., Rapid estimation of hydrophobicity for virtual combinatorial library analysis., SAR and QSAR in Environmental Research, 12(1-2), 2001.

* Mracec, Maria; Oprea, Tudor I.; Mracec, Mircea, Correlation between experimental electron affinities for aromatic derivatives and the values calculated with semiempirical MO methods., Revue Roumaine de Chimie, 45(10), 2000.

Mai jos este tabelul ResearcherID/A-5746-2011 pentru toate articolele cercetatorului Tudor Oprea: