Marilena Plesu (Lupu)

Marilena Plesu's publications focus on various aspects of transplantation biology, stem cell plasticity, histocompatibility testing, graft-versus-host disease prevention and treatment, hematopoietic cell transplantation for the treatment of hematological malignancies and Duchenne muscular dystrophy, the use of placental tissues and bone marrow derived endothelial progenitors in cell therapy for vascular repair and regeneration, and tumor angiogenesis.


Professional experience:


2015-2016 Marie Curie Research Fellow, Institute for Research on Cancer and Aging, Nice (IRCAN), CNRS UMR 7284, INSERM U1081, UNS, Nice, France;

2007-2013 Scientist, Cell Therapy Laboratory, Institute of Cellular Biology and Pathology "Nicolae Simionescu", Bucharest, Romania;

2006-2007 Oncology Fellow, College of Veterinary Medicine, Oregon State University, Corvallis, OR, USA;

2004-2006 Postdoctoral Fellow and PhD Candidate, Clinical Research Division - Transplantation Biology Program, Storb's Laboratory, Fred Hutchinson Cancer Research Center, Seattle, WA, USA;

2002-2004 PhD Candidate, Department of Clinical Sciences - Comparative Oncology Clinic and Teaching Hospital Clinical Laboratory, School of Veterinary Medicine, Bucharest, Romania;

2003 Visiting Trainee - Training in Transfusion Medicine and Autologous Hematopoietic Cell Transplantation, Department of Blood Transfusion and Bone Marrow Transplantation, Clinical Institute “Fundeni“, Bucharest, Romania;

2003 Visiting Trainee - Training in Allogeneic Hematopoietic Cell Transplantation, Stem Cell Aphaeresis Unit, Stem Cell Laboratory and Bone Marrow Transplantation Unit, “Szent László” Hospital, Budapest, Hungary; The HLA-Typing Laboratory, National Institute of Hematology, Budapest, Hungary;

1999-2001 Summer student volunteer research internships in Cancer Biology, Cancer Biology Department, Institute of Oncology “Prof. Dr. Al. Trestioreanu”, Bucharest, Romania.


Grants:

- Experienced Researcher - FP7 Marie Curie Intra-European Fellowship from the European Community: "Investigation of VEGF-C involvement in acquired metastatic properties of renal cell carcinoma following anti-angiogenesis treatments", acronym “VELYMPH”; Duration: 2015-2016;
- Project coordinator - PNCDI-II Grant for the development of a young research team, granted by the Romanian Ministry of Education and Research: "Molecular mechanisms of human umbilical cord-derived stem cells integration and vasculogenesis within the cardiac tissue; implications for cardiovascular regeneration”, acronym “RE-CORD”; Duration: 2010-2013;
- Partner and Scientific coordinator in FP7 Capacities - International Cooperation Grant from the European Community (Research Potential REGPOT-2009-2): “Reinforcement of the Adult stem cell research area through Mobility and Scientific networking between Egypt, Romania and a German consortium for Strengthening the international scientific competency”, acronym “RAMSES”; Duration: 2010-2013;
- Project coordinator - German-Romanian Bilateral Cooperation Grant funded by the Romanian Ministry of Education and Research and the Federal Ministry of Education and Research from Germany: “Bilateral cooperation between Romania and Germany for reinforcing the European scientific competitiveness in the field of stem cell research with applications for cardiovascular regeneration”, acronym “CORES”; Duration: 2009-2010;
- Experienced Researcher - FP7 Marie Curie International Reintegration Grant from the European Community - Support for training and career development of researchers (People 2007-4-3-IRG): "Cell therapy employing endothelial progenitors for experimentally induced cardiac ischemia", acronym “EPETER”; Duration: 2008-2010;
- Project coordinator - PNCDI-II Reintegration Grant from the Romanian Ministry of Education and Research: "Development of cell therapies using endothelial progenitors derived from human bone marrow and placental tissues"; Duration: 2008-2010.


Honors and awards:

2006 "Magna Cum Laude" distinction for PhD thesis research from the Ministry of Education and Research/University of Agronomical Sciences and Veterinary Medicine, Bucharest, Romania;

2004-2006 Fellowship in Oncology and Transplantation Biology from the National Institutes of Health, Bethesda MD, USA;

2003 “Carol Davila” Honor Diploma for research activity in Veterinary and Comparative Oncology from the School of Veterinary Medicine, Bucharest, Romania.


Professional memberships:

2015 French Society of Angiogenesis
2008 Romanian Society of Cell Biology
2007 Ad Astra Association - An Online Project for the Romanian Scientific Community
2006 American Association for the Advancement of Science
2005 American Society of Hematology
2005 Veterinary Cancer Society (USA)
1999 Romanian Society of Comparative Oncology

Institute for Research on Cancer and Aging, Nice, Nice, .

E-mail: trimite un mesaj.

Pagina web personala: http://www.researcherid.com/rid/A-4596-2011

Urmareste linkul ResearcherID pentru toate articolele cercetatorului: A-4596-2011. Tabelul detaliat al articolelor este in josul paginii.

Nascut(a) in: 1977

Interese: normal and pathological angiogenesis, anti-angiogenic therapy, radiobiology, transplant biology, cancer biology, stem cell plasticity, cardiovascular regeneration, cell therapy, hematopoietic cell transplantation, comparative oncology, translational medicine

Detalii:
Publicatiile Marilenei Plesu sunt focalizate pe investigarea implicarii unor molecule pro-(limf)angiogenice in dobandirea proprietatilor metastatice ca urmare a terapiei anti-angiogenice; variate aspecte ale biologiei celulelor stem si progenitoare adulte, terapiei celulare pentru regenerarea vasculara, biologiei transplantului, testarii histocompatibilitatii, preventiei si tratamentului bolii grefa-contra-gazda, precum si ale transplantului de celule hematopoietice pentru tratamentul hemopatiilor maligne si al distrofiei musculare Duchenne.


Experienta profesionala


2015-2016 Marie Curie research fellow, Echipa "Angiogeneza Normala si Patologica", Institute for Research on Cancer and Aging, Nice (IRCAN), CNRS UMR 7284, Nice, France;

2007-2013 Cercetator, Investigator Principal, Conducator de grup, Grupul "Angiogeneza si Remodelare Cardiovasculara", Departamentul de Medicina Regenerativa, Institutul de Biologie si Patologie Celulara "Nicolae Simionescu" al Academiei Romane, Bucuresti, Romania;

2006-2007 Oncology fellow, Colegiul de Medicina Veterinara, Oregon State University, Corvallis, OR, USA;

2004-2006 Doctorand/Postdoctoral fellow, Departamentul de Biologie a Transplantului, Laboratorul Storb, Fred Hutchinson Cancer Research Center, Seattle, WA, USA;

2002-2004 Doctorand cu frecventa, Departamentul de Oncologie Comparata si Laboratorul Clinic, Facultatea de Medicina Veterinara, Bucuresti, Romania;

2003 Training in medicina transfuzionala si transplant autolog de celule hematopoietice, Departmentul de Transfuziologie si Transplant Medular, Institutul Clinic Fundeni, Bucuresti, Romania;

2003 Training in transplant alogenic de celule hematopoietice, Sectia de Afereza a Celulelor Stem, Labortaorul de Procesare a Celulelor Stem si Sectia de Transplant Medular, Spitalul Szent László, Budapesta, Ungaria; Laboratorul de Tipizare HLA, Institutul National de Hematologie, Budapesta, Ungaria;

1999-2001 Practica de vara in studiul biologiei cancerului, Departamentul de Biologie a Cancerului, Institutul Oncologic Prof. dr. Alexandru Trestioreanu, Bucuresti, Romania;


Granturi
- Cercetator cu experienta - Bursa intra-Europeana FP7 Marie Curie finantata de catre Comisia Europeana: "Investigarea implicarii VEGF-C in metastazarea dobandita in urma tratamentelor anti-angiogenice pentru carcinomul renal", acronim "VELYMPH"; Perioada de derulare: 2015-2016;

- Director de proiect - Grant PNCDI-II pentru stimularea formarii de tinere echipe de cercetare independente, finantat de catre Ministerul Educatiei si Cercetarii din Romania: "Investigarea mecanismelor moleculare ale integrarii si vasculogenezei aferente celulelor stem umane derivate din cordonul ombilical; implicatii pentru regenerarea cardiovasculara, acronim “RE-CORD”"; Perioada de derulare: 2010-2013;

- Partener si Coordonator stiintific in Grant FP7 "Capacitati" - Cooperare Internationala finantat de catre Comisia Europeana (Research Potential REGPOT-2009-2): "Reinforcement of the Adult stem cell research area through Mobility and Scientific networking between Egypt, Romania and a German consortium for Strengthening the international scientific competency", acronim "RAMSES"; Perioada de derulare: 2010-2013;

- Director de proiect - Grant de cooperare bilaterala Romano-Germana finantat de catre Ministerele Educatiei si Cercetarii din Romania si Germania: "Cooperare Bilaterala intre Romania si Germania pentru fortificarea competitivitatii stiintifice Europene in domeniul cercetarii celulelor stem cu aplicatii in regenerarea cardio-vasculara", acronim "CORES"; Perioada de derulare: 2009-2010;

- Cercetator cu experienta - Grant de reintegrare FP7 Marie Curie finantat de catre Comisia Europeana - Suport pentru dezvoltarea carierei (People 2007-4-3-IRG): "Terapia celulara cu celule progenitoare endoteliale pentru tratamentul ischemiei cardiace induse experimental", acronim "EPETER"; Perioada de derulare: 2008-2010;

- Director de proiect - Grant de reintegrare PNCDI-II finantat de catre Ministerul Educatiei si Cercetarii din Romania: "Dezvoltarea terapiilor celulare cu ajutorul celulelor progenitoare endoteliale derivate de la nivelul maduvei osoase si placentei umane"; Perioada de derulare: 2008-2010.


Distinctii

2006 Distinctia "Magna Cum Laude" pentru cercetarile doctorale oferita de catre Ministerul Educatiei si Cercetarii/Universitatea de Stiinte Agronomice si Medicina Veterinara, Bucuresti, Romania

2004-2006 Bursa in Oncologie si Biologia Transplantului oferita de catre National Institutes of Health, Bethesda, MD, USA

2003 Diploma de onoare "Carol Davila" pentru activitatea de cercetare in domeniul Oncologiei Comparate oferita de catre Facultatea de Medicina Veterinara, Bucuresti, Romania


Asociatii profesionale

2015 Societatea Franceza de Angiogeneza
2008 Societatea Romana de Biologie Celulara
2007 Asociatia Ad Astra - Proiect online pentru comunitatea stiintifica romaneasca
2006 American Association for the Advancement of Science
2005 American Society of Hematology
2005 Veterinary Cancer Society (USA)
1999 Societatea Romana de Oncologie Comparata

Publicații selectate:

* Maria Cristina Corotchi, Mirel Adrian Popa, Anca Remes, Livia Elena Sima, Ilinca Gussi and Marilena Lupu Plesu, Isolation method and xeno-free culture conditions influence multipotent differentiation capacity of human Wharton's jelly-derived mesenchymal stem cells, Stem Cell Research & Therapy, 4:81, 2013.

* Lupu. M, Khalil M., Andrei E., Iordache F., Hescheler J, Cardiac integration and vasculogenic properties of human umbilical cord blood- and Wharton's jelly-derived progenitor cells , Proceedings: pp. 80-81, 1st Annual Cambridge Stem Cell Symposium: Pluripotency and Development, Cambridge, July 6-7, 2011.

* Lupu M., Khalil M., Andrei E., Iordache F., Pfannkuche K., Neef K., Georgescu A., Buzila C., Brockmeier K., Maniu H., Hescheler J , Integration Properties of Wharton’s Jelly-derived Novel Mesenchymal Stem Cells into Ventricular Slices of Murine Hearts, Cellular Physiology and Biochemistry, 28(1), 2011.

* Lupu M., Khalil M., Iordache F., Andrei E., Pfannkuche K., Spitkovsky D., Baumgartner S., Rubach M., AbdelRazek H., Buzila C., Brockmeier K., Simionescu M., Hescheler J., Maniu H, Direct Contact of Umbilical Cord Blood Endothelial Progenitors with Living Cardiac Tissue is a Requirement for Vascular Tube-like Structures Formation, Journal of Cellular and Molecular Medicine, 15(9), 2011.

* Lupu M., Buzila C., Andrei E., Iordache F., Maniu H, Characterization of human umbilical cord blood- and Wharton’s jelly-derived endothelial progenitors for use in cellular therapy, Proceedings: pp. 27, Adult somatic stem cells: new perspectives, Monaco, November 26-28, 2009.

* Lupu M., Andrei E., Iordache F., Grigorescu G., Buzila C., Maniu H, In vitro angiogenic potential of endothelial progenitors isolated from human Wharton's Jelly, Proceedings: pp. S225, World Conference on regenerative medicine, Lipzig, Germany, October 29-31, 2009.

* Lupu M., Andrei E., Iordache F., Grigorescu G., Buzila C., Maniu H, Isolation and characterization of endothelial progenitor cells from human Wharton’s jelly, Proceedings: pp. 68, IGB Meeting, Stem Cells: From Molecular Physiology to Therapeutic Applications, Capri, Italy, October 10-13, 2009.

* Lupu M., Andrei E., Buzila C., Constantinescu E., Georgescu A., Maniu H, Characterization of human umbilical cord blood-derived endothelial progenitors for use in cellular therapy, Proceedings: pp. 42, Hydra IV: European Summer School – Stem Cells & Regenerative Medicine, Hydra, Greece, September 5-11, 2008.

* Lupu M, Gooley T, Zellmer E, Graves SS, Storb R, Principles of peripheral blood mononuclear cell apheresis in a preclinical canine model of hematopoietic cell transplantation, Journal of Veterinary Internal Medicine, Jan-Feb;22(1), 2008.

* Lupu M.*, Kuhr C.S.*, Storb R. (*equal contribution), Hematopoietic Cell Transplantation Directly into Dystrophic Muscle Fails to Reconstitute Satellite Cells and Myofibers, Biology of Blood and Marrow Transplantation, Aug;13(8), 2007.

* Helfand S.C., Lupu M., Hematopoietic Cytokines: The Interleukin Array, Saunders, Elsevier, Bonagura J.D., Twedt D.C., Evolve Resources for Kirk’s Current Veterinary Therapy XIV, 2009.

* Lupu M, Aspects of the cytological and histological correlative diagnosis in the veterinary medical practice - Oral presentation, Proceedings: Vol. Nat. Conf. Onc. OC3, pp. 176, The National Conference of Oncology. Institute of Oncology Prof. Dr. Al. Trestioreanu, Bucharest, 2001.

* Lupu M., Kuhr C. S., Storb R, Hematopoietic stem cells neither reconstitute satellite cells nor myofibers after direct injection into dystrophic muscle - Poster Session, Proceedings, American Society of Hematology 48th Annual Meeting and Exposition, Orlando, FL, USA, December 9-12, 2006.

* Lupu M., Gooley T., Zellmer E., Storb R, Peripheral blood mononuclear cell apheresis in the canine model of hematopoietic cell transplantation: analysis of donor and apheresis related variables in 120 dogs - Oral presentation, Proceedings, The 26th Annual Conf. of the Veterinary Cancer Society, Callaway Gardens, GA, USA, October 19-22, 2006.

* Lupu M., Kuhr C.S., Tapscott S., Storb R, Hematopoietic stem cells do not reconstitute satellite cells nor myofibers in hematopoietic canine chimeras with X-linked muscular dystrophy - Invited paper - Oral presentation, International Veterinary Information Service, Ithaca NY (www.ivis.org), Last updated: 17-Sep-2006; P4043.0906, Modiano J.F., Genes, Dogs and Cancer: Fourth Annual Canine Cancer Conference, Sept. 14-17, Chicago, IL, USA, 2006.

* Lupu M., Sullivan E., Westfall T., Weigler B., Stroup P., Zellmer E., Kuhr C.S., Storb R, Multi-generation family molecular dog leukocyte antigen (DLA) typing to select a hematopoietic cell transplant donor for the treatment of a dog with spontaneous T-cell lymphoma - Oral presentation, Proceedings, The 30th Congress of the World Small Animal Veterinary Association, Mexico City, Mexico, May 11-14, 2005.

* Lupu M., Storb R, Five decades of progress in haematopoietic cell transplantation based on the preclinical canine model, Veterinary and Comparative Oncology, 5 (1), 2007.

* Lupu M., McCune J.S., Kuhr C.S., Gooley T., Storb R, Pharmacokinetics of oral mycophenolate mofetil in dog: bioavailability studies and the impact of antibiotic therapy, Biology of blood and marrow transplantation, Dec;12(12), 2006.

* Kuhr C.S., Lupu M., Little M.-T., Zellmer E., Sale G.E., Storb R, RDP58 does not prevent graft-versus-host disease after dog leukocyte antigen-nonidentical canine hematopoietic cell transplantation, Transplantation, May 27;81(10), 2006.

* Lupu M, PhD Dissertation ("Magna Cum Laude"): Clinical and Experimental Studies of Hematopoietic Cell Transplantation in Dogs, March, 2006.

* Lupu M., Sullivan E.W., Westfall T.E., Little M.-T., Weigler B.J., Moore P.F., Stroup P.A., Zellmer E., Kuhr C.S., Storb R, Use of multigeneration-family molecular dog leukocyte antigen typing to select a hematopoietic cell transplant donor for a dog with T-cell lymphoma, Journal of the American Veterinary Medical Association, Mar; 228(5), 2006.

* Cringanu D., Tanase A., Birtoiu A., Preda C., Lupu M., Cringanu I, Chemo-hormone-immunotherapy for mammary tumors in dog, Romanian Journal of Comparative Oncology, 7, 2003.

* Lupu M, Aspects of the cytological and histological correlative diagnosis in the veterinary medical practice, Romanian Journal of Comparative Oncology, 4, 2001.