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Florina Raicu

My specific research interest is the study of the human transcriptome based on the characterization global gene expression profiling of normal and pathological male germ cells by microarray analysis and the effect of the Y chromosome genes on brain development. I investigated some Y chromosome haplogrups associated with spermatogenic failure in the Romanian population and the genetic background of male infertility based on the Y chromosome microdeletion analysis. I am also interested in investigations of the androgen receptor (AR) gene mutations associated with Androgen Insensitivity Syndrome, molecular genetics investigations regarding PAX9 gene mutations, molecular genetics ivestigations in ATP7B gene mutations associated with Wilson disease and new analysis methods of the ancient DNA.EDUCATION: 1994 - 1998tFaculty of Biology, University of Bucharest, Specialization in GeneticsBachelor of science in Molecular Biology1998 - 2000tFaculty of Biology, University of Bucharest, Master in Genetics 2004 - 2007tPh.D. school "Functional Neuroimaging: from cells to systems"Institute of Advanced Biomedical Technologies, co-funded by the European Union in the FP3Department of Clinical Sciences and BioimagingG. d'Annunzio Chieti University - Pescara ITALY PhD in Medical Genetics2001 - 2008 Francisc I.Rainer Anthropological Research Institute, Romanian Academy, BucharestMedical Anthropology Department.PhD in Medical Science.EMPLOYMENT:1998 - 2000Francisc I.Rainer Anthropological Research Institute, Romanian Academy, Bucharest - Research scientist (full time)2000 - 2004Institute of Genetics, University of Bucharest - research scientist (full time)2000 - presentFrancisc I.Rainer Anthropological Research Institute, Romanian Academy, Bucharest - Research scientist (part time)2007 - present Carol Davila University of Medicine and Pharmacy, Bucharest, Faculty of Medicine,Genetics Chair - Assistant professorREVIEWER:1. HUMAN MOLECULAR GENETICS - Oxford University Press Online ISSN 1460-2083 (impact factor 8.099)2. JOURNAL OF ANDROLOGY - Allen Press, ISSN0196-3635, American Society of Andrology (impact factor 2.035 )

Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.

E-mail: trimite un mesaj.

Pagina web a instituţiei: http://www.univermed-cdgm.ro

Nascut(a) in: 1975

Interese: genetica moleculara, cromozomul Y, haplogrupuri, microdeletii, infertilitate masculina, tehnologia microarray, biopaleoantropologie, biostatistica

flag Detalii:
Domeniul principal de cercetare este studierea transcriptomului uman bazata pe profilele de expresie genica globala ale celulelor germinale masculine normale si patologice cu ajutorul tehnologiei microarray precum si efectul genelor din cromozomul Y asupra dezvoltarii creierului. Am investigat unele haplogrupuri ale cromozomului Y asociate cu defectele spermatogenezei in populatia Romaniei si bazele genetice ale infertilitatii masculine prin analiza microdeletiilor cromozomului Y. Sunt de asemenea interesata de studiul mutatiilor din receptorul pentru androgeni ce conduc la aparitia sindromului insensibilitatii la androgeni, studiul mutatiilor din gena PAX9 asociate cu defecte in formarea dentitiei, investigatii genetice asupra genei ATP7B ale carei mutatii stau la baza aparitiei bolii Wilson si de noi metode legate de analiza a ADN fosil.

STUDII:
1994 - 1998
Facultatea de Biologie, Universitatea Bucuresti, Specializare in genetica, Diploma de licenta
1998 - 2000
Facultatea de Biologie, Universitatea Bucuresti, Master in Genetica
2004 - 2007
Ph.D. school "Functional Neuroimaging: from cells to systems"
Institute of Advanced Biomedical Technologies, co-funded by the European Union in the FP3
Department of Clinical Sciences and Bioimaging,
Universitatea G. 'Annunzio Chieti - Pescara ITALIA
Bursa
Doctor in genetica moleculara
Titlul tezei de doctorat: "Human transcriptome: characterizing global gene expression profiling of normal and pathological testis by microarray analysis"
2001- 2008
Institutul de Cercetari Antropologice Francisc Rainer al Academiei Romane Bucuresti
Doctor in medicina

EXPERIENTA PROFESIONALA:
1998 - 2000 - Institutul de Cercetari Antropologice Francisc Rainer al Academiei Romane Bucuresti - asistent cercetare- cercetator stiintific (norma intreaga)
2000 - prezent - Institutul de Cercetari Antropologice Francisc Rainer al Academiei Romane Bucuresti - cercetator stiintific (jumatate norma)
Februarie 2000 - februarie 2004 Institutul de Genetica al Universitatii din Bucuresti - asistent cercetare - cercetator stiintific (norma intreaga)
Februarie 2007- prezent UMF Carol Davila Facultatea de Medicina Bucuresti, Catedra de Genetica - asistent universitar

CARTI:
"Metode si principii in genetica moleculara", Relu Cocos, Laurentiu Bohiltea, Florina Raicu, Daniela Neagos, Editura Medicala, 2006
"Incursiune in antropogeneza", Constantin Balaceanu-Stolnici, Cristiana Glavce, Florina Raicu, Ligia Apavaloae, Editura Medicala, 2006

REVIEWER LA URMATOARELE PUBLICATII:
1. HUMAN MOLECULAR GENETICS - Oxford University Press Online ISSN 1460-2083 (impact factor 8.099)
2. JOURNAL OF ANDROLOGY - Allen Press, ISSN0196-3635, American Society of Andrology (impact factor 2.035)

Publicații selectate:

* Gatta V, Raicu F, Ferlin A, Antonucci I, Scioletti AP, Garolla A, Palka G, Foresta C, Stuppia L, Testis transcriptome analysis in male infertility: new insight on the pathogenesis of oligo-azoospermia in cases with and without AZFc microdeletion., BMC Genomics, Jun 24;11:401, 2010.

* F. Raicu, R. Cocoş, A. Şendroiu, D. Neagoş, R. Creţu, C. Glavce, L. Bohîlţea, I. Şendroiu, High prevalence of Wilson disease in a small mountain village in Romania, EUROPEAN HUMAN GENETICS CONFERENCE, Barcelona SPAIN, 2008.

* V. Gatta, F. Raicu, A. Scioletti, A. Ferlin, G. Palka, C. Foresta, L. Stuppia, Gene expression profiling of normal and pathological testis by microarray analysis, EUROPEAN HUMAN GENETICS CONFERENCE, Barcelona SPAIN, 2008.

* Luis Popa, Ionela Moanta, Florina Raicu, Dan Cimponeriu, Apostol Pompilia, Gabi Bordeianu and Lucian Gavrila, Alphoid heteroduplex polymorphism in sample populations of Romania, HUMAN GENOME MEETING, SHANGHAI, CHINA, 2002.

* F. Raicu, L. O. Popa, O. M. Popa, L. Ilinca, L. L. Dracea, B. Marinescu, L. Gavrila, A Romanian population study of 10 Y-chromosome STS loci from infertile men, EUROPEAN HUMAN GENETICS CONFERENCE 2004, INTERNATIONAL CONGRESS CENTER, MUNICH, GERMANY, 2004.

* Schmidt H.D., Glavce C., Raicu F., Apavaloae L., Grasa, C, Frequencies of some Genetic Markers in an Aromun Population in Dobruja, EUROPEAN ANTHROPOLOGICAL ASSOCIATION 14TH INTERNATIONAL CONGRESS HUMAN VARIABILITY: A BRIDGE BETWEEN SCIENCES AND HUMANITIES, Komotini, GREECE, 2004.

* L. Popa, F. di Giacomo, O. Popa, F. Raicu, N. Coman, Remarkable homogeneity of the human Y chromosome P lineage at the level of alphoid heteroduplex polymorphic system, EUROPEAN HUMAN GENETICS CONFERENCES 2006 AMSTERDAM, THE NETHERLANDS, 2006.

* O. Scarciolla, L. Stuppia, M. V. De Angelis, S. Murru, F. Raicu, R. Giuliani, M. Pace, I. Antonucci, A. P. Scioletti, I. Torrente, P. Grammatico, M.C. Rosatelli, A. Uncini, G. Palka, B. Dallapiccola, Spinal muscular Atrophy (smA) genotyping by gene dosage using Multiple Ligation-dependent Probe Amplification (mLPA), EUROPEAN HUMAN GENETICS CONFERENCES 2006 AMSTERDAM, THE NETHERLANDS, 2006.

* Varzari A, Kharkov V, Stephan W, Raicu F, Dergachev V, Puzyrev VP, Stepanov V, Weiss E, Alu polymorphisms and Y-chromosome variation in the Dniester-Carpathian region, THE 9TH INTERNATIONAL MEETING ON HUMAN GENOME VARIATION AND COMPLEX GENOME ANALYSIS, Barcelona, SPAIN, 2007.

* R. Cocoş, F. Raicu, D. Neagoş, Identification of reduced copy number of DAZ genes in a group of Romanian idiopathic infertile men, EUROPEAN HUMAN GENETICS CONFERENCE, Nice Acropolis Center FRANCE, 2007.

* S. Schipor, R. Cocoş, E. Pãune-Buşe, I. Nicolae, R. Creţu, A. Ştefãnescu-Winterlike, F. Raicu, The relationship between the -765G>C COX-2 polymorphism and the development of cutaneous inflammatory process, EUROPEAN HUMAN GENETICS CONFERENCE, Nice Acropolis Center FRANCE, 2007.

* Raicu F, V. Gatta, A. Ferlin, C. Foresta, G. Palka, L. Stuppia, Expression profiling of human normal testis by microarray technology, EUROPEAN HUMAN GENETICS CONFERENCE, Nice Acropolis Center FRANCE, 2007.

* Tete S, Mastrangelo F, Scioletti AP, Tranasi M, Raicu F, Paolantonio M, Stuppia L, Vinci R, Gherlone E, Ciampoli C, Sberna MT, Conti P., Microarray expression profiling of human dental pulp from single subject, Clin. Invest. Med, 31(2), 2008.

* Florina Raicu, R. Giuliani, V. Gatta, C. Palka, P. Guanciali Franchi, P. Lelli-Chiesa, S. Tumini, L.Stuppia, A Novel Mutation in the Ligand-Binding Domain of the Androgen Receptor gene (L790P) associated with Complete Androgen Insensitivity Syndrome, Asian Journal of Andrology, Jul;10(4), 2008.

* A Ferlin, F Raicu, V Gatta, D Zuccarello, G Palka, C Foresta, Male infertility: role of genetic background, Reproductive BioMedicine Online, Vol 14. No 6, 2007.

* Varzari A, Stephan W, Stepanov V, Raicu F, Cojocaru R, Roschin Y, Glavce C, Dergachev V, Spiridonova M, Schmidt HD, Weiss E., Population history of the Dniester-Carpathians: evidence from Alu markers, Journal of Human Genetics, 52(4):, 2007.

* Vinci G, Raicu F, Popa L, Popa O, Cocos R, McElreavey K.,, A deletion of a novel heat shock gene on the Y chromosome associated with azoospermia, Molecular Human Reproduction, Apr;11(4), 2005.

* Popa LO, Di Giacomo F, Popa OM, Raicu F, Coman N., Multiplex PCR for the assignment of some major branches of the Y chromosome tree, Journal of Genetics, dec;84(3), 2005.

* Florina Raicu , L. Popa , Pompilia Apostol , D. Cimponeriu , Letitia Dan , Elena Ilinca , Laura Luana Dracea , B. Marinescu , L. Gavrila, Screening for microdeletions in human Y chromosome -AZF candidate genes and male infertility, Journal of Cellular and Molecular Medicine, vol.7, nr.1, 2003.