Sorin Tunaru

PhD in Human Sciences (Dr.Sc.Hum), University of Heidelberg (Germany)in 2005Currently, Project Leader at Max-Planck Institute for Heart and Lung Research, Bad Nauheim, Germany----Interested in the biological effects of lipid metabolites, molecular biology of G-protein coupled receptors.

Max-Planck Institute for Heart and Lung Research, Bad Nauheim, .

E-mail: trimite un mesaj.

Urmareste linkul ResearcherID pentru toate articolele cercetatorului: G-8516-2011. Tabelul detaliat al articolelor este in josul paginii.

Nascut(a) in: 1976

Publicații selectate:

* Tang C, Ahmed K, Gille A, Lu S, Gröne HJ, Tunaru S, Offermanns S, Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes., Nature Medicine, Jan 12, 2015.

* Preuß B1, Tunaru S, Henes J, Offermanns S, Klein R., A novel luminescence-based method for the detection of functionally active antibodies to muscarinic acetylcholine receptors of the M3 type (mAchR3) in patients' sera., Clin Exp Immunol., 2014.

* Conzelmann M, Williams EA, Tunaru S, Randel N, Shahidi R, Asadulina A, Berger J, Offermanns S, Jékely G., Conserved MIP receptor-ligand pair regulates Platynereis larval settlement., Proc Natl Acad Sci U S A., 110(20), 2013.

* Sorin Tunaru, Till F. Althoff, Rolf M. Nüsing, Martin Diener, and Stefan Offermanns, Castor oil induces laxation and uterus contraction via ricinoleic acid activating prostaglandin EP3 receptors, Proc Natl Acad Sci U S A., 2012.

* Layer, PG; Tunaru, S; Volpert, K, GDNF affects proliferation and apoptosis during retinal development in reaggregation cultures of the chick., Investigative Ophthalmology & Visual Science, 42, 2001.

* Tunaru, S; Brulet, P; Offermanns, S;, Generation of a reporter cell line for measuring intracellular calcium dynamics based on chemiluminescence resonance energy transfer., : Naunyn-Schmiedebergs Archives of Pharmacology, 365, 2002.

* Lukasova M, Hanson J, Tunaru S, Offermanns S., Nicotinic acid (niacin): new lipid-independent mechanisms of action and therapeutic potentials., Trends Pharmacol Sci., Dec;32(12), 2011.

* Hanson J, Gille A, Zwykiel S, Lukasova M, Clausen BE, Ahmed K, Tunaru S, Wirth A, Offermanns S., Nicotinic acid- and monomethyl fumarate-induced flushing involves GPR109A expressed by keratinocytes and COX-2-dependent prostanoid formation in mice., J Clin Invest, Aug 2;120(8), 2010.

* Ahmed K, Tunaru S, Tang C, Müller M, Gille A, Sassmann A, Hanson J, Offermanns S., An autocrine lactate loop mediates insulin-dependent inhibition of lipolysis through GPR81., Cell Metab, Apr 7;11(4), 2010.

* Ahmed K, Tunaru S, Offermanns S., GPR109A, GPR109B and GPR81, a family of hydroxy-carboxylic acid receptors., Trends Pharmacol Sci, 30(11), 2009.

* Ahmed K, Tunaru S, Langhans CD, Hanson J, Michalski CW, Kölker S, Jones PM, Okun JG, Offermanns S., Deorphanization of GPR109B as a receptor for the beta-oxidation intermediate 3-OH-octanoic acid and its role in the regulation of lipolysis, J Biol Chem., ;284(33), 2009.

* Kero J, Ahmed K, Wettschureck N, Tunaru S, Wintermantel T, Greiner E, Schütz G, Offermanns S., Thyrocyte-specific Gq/G11 deficiency impairs thyroid function and prevents goiter development., J Clin Invest, Sep;117(9), 2007.

* Tunaru S, Lättig J, Kero J, Krause G, Offermanns S, Characterization of determinants of ligand binding to the nicotinic acid receptor GPR109A (HM74A/PUMA-G)., Mol Pharmacol., Nov;68(5), 2005.

* Niedernberg A, Tunaru S, Blaukat A, Harris B, Kostenis E., Comparative analysis of functional assays for characterization of agonist ligands at G protein-coupled receptors., J Biomol Screen., Oct;8(5), 2003.

* Niedernberg A, Tunaru S, Blaukat A, Ardati A, Kostenis E, Sphingosine 1-phosphate and dioleoylphosphatidic acid are low affinity agonists for the orphan receptor GPR63., Cell Signal., Apr;15(4):, 2003.

* Tunaru S, Kero J, Schaub A, Wufka C, Blaukat A, Pfeffer K, Offermanns S., PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect, Nat Med, Mar;9(3), 2003.