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Aurelian Udristioiu

Aurelian Udristioiu

Curriculum Vitae

PERSONAL DETAILS:

First name: AURELIAN
Surname: UDRISTIOIU
Specialty: European Specialist in Laboratory Medicine
Age: 62
Gender: Male
Date of Birth: /05/11/
Citizenship: Romanian
Home Address: Traian Street, No: 26, City: Targu-Jiu, Romania
Telephone: 40723621414; 40723565637.
Email Address: aurelianu2007@yahoo.com
Reason for applying to work abroad: Passion for works of researches in onco-hematology field
aurelian-udristioiu.strikingly.com

Available From (Month, Year): October First, / 2016-05-01
aurelian-udristioiu.strikingly.com
LANGUAGE SKILLS:

Language Level
ENGLISH 8
ITALIAN 9
RUSSIAN 5
ARABIC 3

MEDICAL AUTHORITY REGISTRATIONS:

Medical Authority Registration Number
European Specialist in Biochemistry and Laboratory Medicine, License to practice in: EUROPEN UNION-EU
Certificate of Conformity, BUCHAREST, ROMANIA.

My GMC Reference Number in UK: 7480781 NO. VIII. d / 55001 / 19. 10. 2007
EDUCATION AND POST GRADUATE EXAMS PASSED:

-High School, Liceul Pedagogic, (Teacher), City Targu Jiu, County Gorj, Romania, 1972-1\

-Faculty of General Medicine CRAIOVA, Romania, September 1977-September 1983

-Practitioner Medic of General Medicine (Stage), in University Hospital Grivita, (Sfanta Maria), Bucharest, District 1, Romania, October 1983-November 1986.

-General Practitioner in County Gorj, Hospital Motru,City Motru, Romania, December -1986-November 1989
-Physician Resident in Laboratory Medicine and Microbiology,-14 November 1989 to 14 November 1992.
--Master in Hematology, Laboratory Medicine, University Hospital Careggi, Agienda Carregy, Universita degli Studi Firenzze, Florence, Italy, January 1995-June 1995.

Fellow PhD in molecular biology, Titu Maiorescu University, General Medicine Faculty, Bucharest, Romania.
COURSES COMPLETED:
Name of course Date Completed
Laboratory Onco-Hematology , University Hospital Fundeni, Romania/780,MS Ian 1993-Mai 1993
Screening , col cancer uterine , Babes Papanicolau 10 Oct 2013-13 Oct 2013

Course of Mass-Spectrometry IPC-MS
9 Sept. 2012-15 Sept. 2012.

CURRENT EMPLOYMENT:

From: Month, Year To: Month, Year Hospital Country Position Title
August, 1998 May/2015 and in present EMERGENCY COUNTY HOSPITAL
TARGU JIU Romania Primary Physician in Laboratory Medicine

Name and address of the hospital:
Emergency County Hospital TARGU-JIU,.Progresului Street No.18,Gorj, Postal Code:Zip 210218,Romania; Fax :00-40-253-210432 ;Phone :00-40-723621414.
HOSPITAL DESCRIPTION
Specialties Internal Medicine, Gynecology, Neurology, Oncology, Emergency Medicine.
No. of hospital beds 1200
Outpatient services offered: Diagnostics Diseases, Treatment, Laboratory Investigations.



PREVIOUS EMPLOYMENT:

Physician Specialist of Laboratory Medicine, in Hospital Rovinari, County Gorj, Romania, December 1992-September 1993

-Physician Specialist of Laboratory Medicine September 1993-1995, in Hospital City Nalut and Kabaw, Lybia.

- September 1996-1998, 31 August, Physician Specialist of Laboratory Medicine and Primary Physician of Laboratory Medicine ( from 18-09-1997) in University Hospital Bucharest, Romania

-Primary Physician of Laboratory Medicine, from 31-08-1998 until present/2015, in Emergency County Hospital Targu Jiu, City Targu Jiu, Romania.


SUMMARY OF EXPERIENCE- BY SKILL
Skill Number of procedures undertaken: From: (Month,Year) To:
(Month,Year)

-Perform and Validation of Laboratory Analyses.

-I Assure the Quality Control of medical laboratory analyses, QC, PT ( Proeficiency Testing),

-Auditor Accredited on the International Standard; ISO: 15189/2013.

I performed in Departments of Laboratory Medical Analyses:
-HEMATOLOGY, Analysis of Laboratory, per every year/15 000.
- MICROBIOLOGY, Analysis of Laboratory, per every year/500
- CLINICAL CHEMISTRY, Analysis of Laboratory, perevery year/20 000. August, 1998 March, 2015
Works of researches, in Laboratory medicine field 11 August, 1998 June, 2015

RECENT WORK OF RESEARCHES

1. Udristioiu A. The Assessment of Uncertainty in Measurement of Cholesterol; A Model of Calculation. Biophysical Journal; Volume 96, Issue 3, Supplement 1, February 2009; Page 504a.

2. Udristioiu A, Florescu Cristina, Popescu Manuela Andrei. “High Concentration of anaerobic ATP implicated in aborted apoptosis from CLL”. LabMedicine, American Journal of Clinical Pathology-ASCP, Manuscript 09-08-LM-S-SCI-0122R1, Published in 04-05/2010.

3. Aurelian Udristioiu. First Hematological Signal of Latent Anemia to Aging Population. Nature Publishing Group. Advance Search 0.1038 npre 2009.3285.1. Creative Common Attribution 3.0 License, accepted for the work online posted.

4. Udristioiu A, Cojocaru M, Florescu C. Screening Tests for Latent Anemia in Hospitalized Adults Over 65. LabMedicine, American Journal of Clinical Pathology-ASCP, Manuscript 09-11-LM-S-SCI-0156.R1, Published in 07-05/2010.USA American Journal of Clinical Pathology p-ISSN: 0002-9173 ICV 38.53 LabMedicine ; Ascp Press) , Impact Factor ISI, IF = 2.853 , 18 Index Copernicus Journals Master List 2006.

5. PHENOTYPIC AND GENOTYPIC CHARACTERIZATION OF ANTIBIOTIC RESISTANCE PATTERNS IN ACINETOBACTER BAUMANNII STRAINS ISOLATED IN A ROMANIAN HOSPITAL. MANUELA-ANDA RADU-POPESCU1*, SILVIA DUMITRIU2,SIMONA ENACHE-SOARE3, GABRIELA BANCESCU2, AURELIANUDRISTOIU4, MANOLE COJOCARU5, CODRUTA VAGU6
1 University of Medicine and Pharmacy “Carol Davila, Faculty of Pharmacy, Department of Microbiology, Traian Vuia 6, Sect. 2, 020956,Bucharest, Romania.
6“Stefan S. Nicolau” Virology Institute, Bucharest, Romania. FARMACIA 2010; (57); 3: 420-427 IMPACT FACTOR ISI THOMSON 0.144 .

6. Moleular Biological Tchiniques user for identification of Candida SPP. MANUELA-ANDA RADU-POPESCU1*, SILVIA DUMITRIU2, SIMONA ENACHE-SOARE3, AURELIAN UDRISTOIU4. 1 University of Medicine and Pharmacy “Carol Davila, Faculty of Pharmacy. FARMACIA 2010; (58); 4: 422-429

7. Udristioiu A. Role of Mg2+ ion as cofactor ATP in assurance of energetic environment cells( Abstract). Magnesium Research 2011; 24 (1): 22-6.

8. -Aurelian Udristioiu, Radu G. Iliescu, Cristina Popescu. Variability of bilirubin values in serum samples with high triglycerides; interference or congenital liver syndromes. J Biosci Tech Volume 2, Issue 4 (JULY 2011).

9. Aurelian Udristioiu¹*,Radu G. Iliescu², Lucian Udristioiu¹ and Manole Cojocaru. A new approach of abnormal apoptosis as a cause of autoimmunity and malignancy. Biotechnology and Molecular Biology Review Vol. 6(8), pp. 166-171, November 2011 . Available online at

10. Aurelian Udristioiu, Cristina Popescu, Manole Cojocaru, Sorina Comisel, Valentina Uscatescu. Relation between LDH and Mg as Factors of Interest in the Monitoring and Prognoses of Cancer. Journal of Bioanalysis & Biomedicine. Ref.: Ms. No. JBABM-11-48R1 accepted on Jan 27, 2012

11. UDRISTIOIU A. Florescu C, Popescu C, Cojocaru M "Significance of Neutrophil Alkaline Phosphatase versus Isoenzymes ALP in Acute or Chronic Diseases,"accepted for publication in LabMedicine, LabMedicine Manuscript 11-03-LM-U-MR-0052.R2/11/12/2011.

12. Aurelian Udristioiu¹, Radu Iliescu ², Manole Cojocaru³. Errors in Counting Platelets in Hemodialysis 12PatAurients by Use of Optical Microscopy. Review of Applied Physics (RAP) Volume 2 Issue 1, March 2013; p: 17-22

13. Aurelian Udristioiu¹, Radu Iliescu ², Manole Cojocaru³. Energetic Levels of Metabolic Pathways in Malignant B and T Cells Mini-Review. Advances in Chemical Science Volume 2 Issue 4, December 2013; 2; 90-95

14. Aurelian Udristioiu¹, Manole Cojocaru² Hemolytic Anemia Drugs Induced by Antihypertensive Agents: A case of Laboratory. 13 Scholars Journal of Medical Case Reports ISSN 2347- 6559. Sch J Med Case Rep 2013; 1(1):8-11

15. Aurelian Udristioiu1*, Radu G. Iliescu2, Manole Cojoraru Molecular mechanisms of bone reconstruction in new dental implant technology. Integrated Journal of British. Volume 1 2014 Issue 1(5-6), pg: 1-7; IJBRITISH.

16. Aurelian Udristioiu¹, Staniloiu Mihail¹, Manole Cojocaru², Sorina Comisel³.
Molecular mechanisms of bone reconstruction in new dental implant technology.
App. Sci. Report. 10 (2), 2015: 50-54.

17. Aurelian Udristioiu. Infrared Spectrum of Human Bio-energetic Field. . Open Science Journal of Bioscience and Bioengineering 2015; 2(6): 63-67. Published online October 13, 2015 (http://www.openscienceonline.com/journal/bio)

18. Arelian Udristioiu. Medical Risck and Clinical Safety in Emegency Medicine. (Paper Conferece, Viena, 09/15-17/2015). Romania Journal of Health Manager 2015; An. 3, ISSN 2344-6625, Nr. 9(4): 17-20.

19. Aurelian Udristioiuᶪ, Manole Cojocaru². Risk of Dis-lipids Syndrome in Modern Society. International Journal of Health Sciences & Research (ISSN: 2249-9571 VOL 2 ISSUE 1 January 2016 Paper 4


WRITEN BOOKS:

1.Aurelian Udristioiu. “Fitness Bike and Health”. Ed. Medicala 1990, Bucuresti. ISBN: 973-39-01105-9; Formatul 16/10 x 100; Nr pagini: 78.

2.Aurelian Udristioiu. “Bioenergetics of malign and normal cells” Ed. Academica Brancusi 2002, Targu Jiu, Bun de tipar, Bucuresti, Tipografia Everest 2001; ISBN 973 85342-6-7; Formatul 16/14 x 100; Nr. Pagini: 307.

3. Aurelian Udristioiu, Manole Cojocaru, Radu Iliescu., “Hematological and Metabolic Aspects from Laboratory Medicine" (ISBN 978-3-8473-0775-4). LAP LAMBERT Academic Publishing GmbH & Co. KG Heinrich-Böcking-Str. 6-8 , 66121, Saarbrücken, Germany, 2012.

4. Book title: Renal Diseases / Book 2 (ISBN 979-953-307-704-7). Chapter title: Variability of Biological Parameters in Blood Samples between Two Consecutive Schedules of Hemodyalsis
Authors: Aurelian Udristioiu, Manole Cojocaru, Victor Dumitrascu, Daliborca Cristina Vlad, Alexandra Dana Maria Panait and Radu Iliescu, Publishing Group 2011, Volume 2, Issue 4 (JULY 2011).

5. e-BOOK: Hematological and Metabolical Aspects of Laboratory Medicine (Hematological and Metabolical Aspects from Laboratory Medicine) ( Second Edition ) [Large Print] [Paperback]. Publisher: Aurelian Udristioiu; 2 edition (September 9, 2013); Full Color on White paper, 122 pages. ISBN-13: 978-1492186816

6. Book:” Recent Developments in Biotechnology, Volume 9: Diseases and Theranostics”, Author: Surender Singh. Chapter 21, Energetic Levels of Metabolic Pathways in Malignant B and T Cells Mini-review, Author Aurelian Udristioiu, Manole Cojocaru, ISBN: 9781626990241, Pages: 530, Publisher: Studium Press LLC, Year: 2014.

7. Udristioiu A, e-Book Hematological and Metabolically Aspects of Laboratory Medicine
(3-th Edition in New Review). Publisher: Aurelian Udristioiu, (EDITOR) (ID:7194451) Edition (March 13, 2016). Amazon Digital Services LLC . ASIN: B01CYY2B7E.


TEACHING RESPONSIBILITIES:

Speciality/area of responsibility From: (Month,Year) To:
(Month,Year)
Lab Director of Laboratory Analyses
Prymary Physician August 1998
April 2015 April 2015

Im present




NATIONAL AND INTERNATIONAL AWARDS

- Aurelian Udristioiu, Member in :National Academy of Clinical Biochemistry, NACB, Washington, D.C, USA.

- Aurelian Udristioiu. Anti-miocard Antibodies in Rheumatic Fever, Measured by Immunofluorescence, Medical Days, Craiova – May 1983. – Premium III Diploma.

- Aurelian Udristioiu. International Travel Grant AACC:
Winner/56-th Annual Meeting AACC, 08/25-29/2004, Los Angeles, California, USA.

-Aurelian Udristioiu. International Travel Grant AACC,
Winner/57-th Annual Meeting AACC, 07/24-28/2005, Orlando (FL), USA.
- Aurelian Udristioiu. Award: Clinical Chemist`s Recognition Award/2007-2008 and Award/2009, AACC, Washington al Society, since 2008, Columbus, (OH), USA.

-Aurelian Udristioiu, ‘ Who is Who in Romania/2009’Romanian Personality in Book Enciclopedy
-Aurelian Udristioiu. Award: Clinical Chemist`s Recognition Award/2007-2008 and Award/2009, AACC, Washington .
- Aurelian Udristioiu, ‘ Who is Who in medical departments USA/ 2011-2012: Who's Who in Medicine and Healthcare
2011-2012-2013-2014-2015 (8th Edition)
” MarquisWho'sWho” , 300 ConnellDrive, Suite 2000, Berkeley Heights, N0: 07922 USA1-908-673-1000 , www.marquiswhoswho.com

-Professional 1 Member in American Society of Clinical Laboratory(ASCLS), Bethesda, USA, since 07/31/2006; Member ID#= 219762.

- Aurelian Udristioiu, Certificate as Award Academic Editor International UK: SCIENCEDOMAIN international Journal/2015.

- Aurelian Udristioiu, Certificate as Award Academic, IBC, International Bibliographic Centre, Cambridge, UK, 2015.

- Aurelian Udristioiu, Man of medicine on year/2015, Certificate as Award Academic, IBC, International Bibliographic Centre, Cambridge, UK, 2015.
REFERENCE
Name: Hospital: Contact phone number: Email address:
Manole Cojocaru
Titu Maiorescu University, Faculty of Medicine, Physiology Department, Bucharest, Romania; 40723326663 manole.cojocaru@yahoo.com

Dana Alexandra Maria Panait Titu Maiorescu University, Faculty of Medicine, Microbiology Department, Bucharest, Romania 40720949055 dana2pan@yahoo.com

16-04-2016

2012 Clinical Chemist Recognition Award AACC, USA

The Clinical Chemist Recognition Award is given to AACC members who have earned at least 75 continuing education credits (ACCENT®,CME, or PACE or other accepted credits) over the past three years. The following recipients earned this award for their participation in accredited continuing education activities from 2007 through 2009. Congratulations to all of you!
-Sarfraz Ahmad, PhD -Petros C. Loizou
Paralimni, Cyprus
-Qing Meng, MD, PhD
Saskatoon, SK, Canada
-Alejandro Molinelli, PhD
Memphis, TN
-Karla Murphy, MD
Sioux Falls, SD
-George Pappas
Charleston, SC
-Yeshwant Purandare, PhD
Farmingdale, NY
-Joseph Quashnock, PhD
Bridgeville, PA
-A. Mabood Qureshi, MSc
Saskatoon, SK, Canada
-Udayan Ray, MD, PhD
Tasmania, Australia
-Philip Rosenthal, MD -Wayne Ross, MCLS, MT
Wallingford, CT
-William Simpson, MB
Aberdeen, United Kingdom
-Ravinder Singh, PhD
Rochester, MN
-Jane S-C Tsai, PhD
Indianapolis, IN
-Aurelian Udristioiu, MD ,Targu Jiu, Romania
-Denise Uettwiller-Geiger, PhD, Port Jefferson, NY
=Lynn Witherspoon, MD
New Orleans, LA
-Eugenio H. Zabaleta, PhD
Mansfield, OH
-Yusheng Zhu, PhD







LISTA LUCRARI CERCETARE ISI/2011-2016


-Biophysical Journal's impact factor for 2009 = 4.39, two article published, Full Author Aurelian Udristioiu.
-LabMedicine, Impact Factor ISI, IF = 2.853, 18 Index Copernicus Journals Master List 2006 = 2 works published = 2 x 2.853 =5.706, Full Author Aurelian Udristioiu.
-Farmacia University of Medicine and Pharmacy “Carol Davila, Bucharest 2010; (57); 3: 420-427, Imp act Factor ISI Thomson = 0.144, 2 works published, as co-author, Aurelian udristioiu
-.Magnesium Research 2011; 24 (1): 22-6. ISI, Impact Factor = 0.40, one article, Full Author Aurelian Udristioiu.

-Udristioiu A. Atihypertensive Agents: A case of Laboratory. 13 Scholars Journal of Medical Case Reports ISSN 2347- 6559. Sch J Med Case Rep 2013; 1(1):8-11
-Aurelian Udristioiu1*, Radu G. Iliescu2, Manole Cojoraru Molecular mechanisms of bone reconstruction in new dental implant technology. Integrated Journal of British. Volume 1 2014 Issue 1(5-6), pg: 1-7; IJBRITISH.

-Aurelian Udristioiu¹, Staniloiu Mihail¹, Manole Cojocaru², Sorina Comisel³.
Molecular mechanisms of bone reconstruction in new dental implant technology.
App. Sci. Report. 10 (2), 2015: 50-54.

-Aurelian Udristioiu. Infrared Spectrum of Human Bio-energetic Field. . Open Science Journal of Bioscience and Bioengineering 2015; 2(6): 63-67. Published online October 13, 2015 (http://www.openscienceonline.com/journal/bio

- Aurelian Udristioiuᶪ, Manole Cojocaru². Risk of Dis-lipids Syndrome in Modern Society. International Journal for Research in Health Sciences and Nursing. VOL 2 ISSUE 1 January 2016 Paper 4. International Journal of Health Sciences & Research (ISSN: 2249-9571) is indexed/included in the following database.

Scopemed, DOAJ, Index Copernicus (ICV: 92.82), Google Scholar, Google, HINARI (WHO, Geneva), Genamics, Open Science Directory, AGORA, BOAI, SOROS, Scirus, Index Scholar, Journal Index, eJManager, Find ejournal, NEWJOUR, Open J-Gate, ICMJE, WorldCat, AcademicKeys, Docstoc, ResearchBib, CiteFactor, getCITED, Ulrich’s International Directory and Other Databases.

Impact Factor: 3.5

-Aurelian Udristioiu¹*,Radu G. Iliescu², Lucian Udristioiu¹ and Manole Cojocaru. A new approach of abnormal apoptosis as a cause of autoimmunity and malignancy. Biotechnology and Molecular Biology Review Vol. 6(8), pp. 166-171, November 2011 . Available online at

-Aurelian Udristioiu, Cristina Popescu, Manole Cojocaru, Sorina Comisel, Valentina Uscatescu. Relation between LDH and Mg as Factors of Interest in the Monitoring and Prognoses of Cancer. Journal of Bioanalysis & Biomedicine. Ref.: Ms. No. JBABM-11-48R1 accepted on Jan 27, 2012

-UDRISTIOIU A. Florescu C, Popescu C, Cojocaru M "Significance of Neutrophil Alkaline Phosphatase versus Isoenzymes ALP in Acute or Chronic Diseases,"accepted for publication in LabMedicine, LabMedicine Manuscript 11-03-LM-U-MR-0052.R2/11/12/2011.

-Aurelian Udristioiu¹, Radu Iliescu ², Manole Cojocaru³. Errors in Counting Platelets in Hemodialysis 12PatAurients by Use of Optical Microscopy. Review of Applied Physics (RAP) Volume 2 Issue 1, March 2013; p: 17-22

-Aurelian Udristioiu¹, Radu Iliescu ², Manole Cojocaru³. Energetic Levels of Metabolic Pathways in Malignant B and T Cells Mini-Review. Advances in Chemical Science Volume 2 Issue 4, December 2013; 2; 90-95

TOTAL IMPACT FACTOR: = 15.126
International Project In Tech Publishing Group, Web: http://www.intechweb.org/ , Book title: Renal Diseases / Book 2’ “Chapter title: Variability of Biological Parameters in Blood Samples between Two Consecutive Schedules of Hemodyalsis “
1. CITATION in Journal: “International Journal of Cancer” –USA, in the work of research” Cyclic nucleotide phosphodiesterase 7B mRNA: an unfavorable characteristic in chronic lymphocytic leukemia” . Author: Zhang, Lingzhi; University of California, San Diego, and all: Murray, Fiona; University of California, San Diego. Rassenti, Laura; University of California, San Diego. Lingzhi Zhang1, Article first published online: 11 FEB 2011. Wiley - Manuscript type: Early Detection and Diagnosis. Reference 1: Udristioiu A. and Co. “Chronic lymphocytic leukemia (CLL).

2. rahmafitri-11247-1.. - Universitas Hasanuddin
repository.unhas.ac.id
Citation /2016: Aurelian, U., Radu, G., Iliescu, Manole, C. and Adela, J. 2014. Alkaline Phosphatase Isoenzymes and Leukocyte Alkaline Phosphatase Score in Patients with Acute and Chronic Disease: A Brief Review.

2.

Emergency County Hospital Targu Jiu, Targu Jiu, Romania.

E-mail: trimite un mesaj.

Pagina web a instituţiei: http://aurelianudristioiu.blogspot.com
Pagina web personala: http://aurelianudristioiu.blogspot.com

Urmareste linkul ResearcherID pentru toate articolele cercetatorului: Password: db5192, URL: www.uefiscdi-direct.ro. . Tabelul detaliat al articolelor este in josul paginii.

Nascut(a) in: 1954

Interese: anemia, leukemia, apoptosis, LLC, p-53 protein, cancer, carcinogenesis process

flag Detalii:
Telephone (work): 40253243315/ext 350

Statement

- My Book written in Clinical Laboratory Medicine, “ Hematological and Metabolically Aspects from Laboratory Medicine” , confirm the aria of my interest in discovery of carcinogenesis mechanisms, especially in onco-haematology field, Leukemia.
Seller www.amazon.com , www.alibris.com

-Also, my new e-Book; Hematological and Metabolically Aspects of Laboratory Medicine ( Second Edition ) [Large Print] [Paperback].
Publisher: Aurelian Udristioiu, 2 edition (September 9, 2013) Full Color on White paper, 122 pages. ISBN-13: 978-1492186816 (CreateSpace-Assigned) ISBN-10: 1492186813, BISAC: Medical / Laboratory Medicine, USA. Sold by www.amazon.com

-Please, see the Blog of my Medical Book :
http://aurelianudristioiu.blogspot.com
http://medicallaboratorybooks.yolasite.com
site-834078-7539-2583.strikingly.com

aurelian-udristioiu.strikingly.com

Thanks.~!
- Aurelian Udristioiu, M.D,
- Primary Physician, EuSpLM,
- City Targu Jiu, Romania
-National Academy of Biochemical Chemistry (NACB) Member, Washington D.C, USA.
-Fellow PhD in Molecular Biology, Titu Maiorescu University, General Medicine Faculty, Bucharest, Romania.
-Man of Medical Year/2015 at the International Bibliographic Center, IBC, Cambridge, UK.

RECENT WORK OF RESEARCHES

1. Udristioiu A. The Assessment of Uncertainty in Measurement of Cholesterol; A Model of Calculation. Biophysical Journal; Volume 96, Issue 3, Supplement 1, February 2009; Page 504a.
2. Udristioiu A, Florescu Cristina, Popescu Manuela Andrei. “High Concentration of anaerobic ATP implicated in aborted apoptosis from CLL”. LabMedicine, American Journal of Clinical Pathology-ASCP, Manuscript 09-08-LM-S-SCI-0122R1, Published in 04-05/2010.
3. Aurelian Udristioiu. First Hematological Signal of Latent Anemia to Aging Population. Nature Publishing Group. Advance Search 0.1038 npre 2009.3285.1. Creative Common Attribution 3.0 License, accepted for the work online posted.
4. Udristioiu A, Cojocaru M, Florescu C. Screening Tests for Latent Anemia in Hospitalized Adults Over 65. LabMedicine, American Journal of Clinical Pathology-ASCP, Manuscript 09-11-LM-S-SCI-0156.R1, Published in 07-05/2010.USA American Journal of Clinical Pathology p-ISSN: 0002-9173 ICV 38.53 LabMedicine ; Ascp Press) , Impact Factor ISI, IF = 2.853 , 18 Index Copernicus Journals Master List 2006.
5. PHENOTYPIC AND GENOTYPIC CHARACTERIZATION OF ANTIBIOTIC RESISTANCE PATTERNS IN ACINETOBACTER BAUMANNII STRAINS ISOLATED IN A ROMANIAN HOSPITAL. MANUELA-ANDA RADU-POPESCU1*, SILVIA DUMITRIU2,SIMONA ENACHE-SOARE3, GABRIELA BANCESCU2, AURELIANUDRISTOIU4, MANOLE COJOCARU5, CODRUTA VAGU6
1 University of Medicine and Pharmacy “Carol Davila, Faculty of Pharmacy, Department of Microbiology, Traian Vuia 6, Sect. 2, 020956,Bucharest, Romania. 6“Stefan S. Nicolau” Virology Institute, Bucharest, Romania. FARMACIA 2010; (57); 3: 420-427 IMPACT FACTOR ISI THOMSON 0.144 .
6. Moleular Biological Tchiniques user for identification of Candida SPP. MANUELA-ANDA RADU-POPESCU1*, SILVIA DUMITRIU2, SIMONA ENACHE-SOARE3, AURELIAN UDRISTOIU4. 1 University of Medicine and Pharmacy “Carol Davila, Faculty of Pharmacy. FARMACIA 2010; (58); 4: 422-429
7. Udristioiu A. Role of Mg2+ ion as cofactor ATP in assurance of energetic environment cells( Abstract). Magnesium Research 2011; 24 (1): 22-6.
8. -Aurelian Udristioiu, Radu G. Iliescu, Cristina Popescu. Variability of bilirubin values in serum samples with high triglycerides; interference or congenital liver syndromes. J Biosci Tech Volume 2, Issue 4 (JULY 2011).
9. Aurelian Udristioiu¹*,Radu G. Iliescu², Lucian Udristioiu¹ and Manole Cojocaru. A new approach of abnormal apoptosis as a cause of autoimmunity and malignancy. Biotechnology and Molecular Biology Review Vol. 6(8), pp. 166-171, November 2011 . Available online at < http://www.academicjournals.org/BMBR>
10. Aurelian Udristioiu, Cristina Popescu, Manole Cojocaru, Sorina Comisel, Valentina Uscatescu. Relation between LDH and Mg as Factors of Interest in the Monitoring and Prognoses of Cancer. Journal of Bioanalysis & Biomedicine. Ref.: Ms. No. JBABM-11-48R1 accepted on Jan 27, 2012
11. UDRISTIOIU A. Florescu C, Popescu C, Cojocaru M "Significance of Neutrophil Alkaline Phosphatase versus Isoenzymes ALP in Acute or Chronic Diseases,"accepted for publication in LabMedicine, LabMedicine Manuscript 11-03-LM-U-MR-0052.R2/11/12/2011.
12. Aurelian Udristioiu¹, Radu Iliescu ², Manole Cojocaru³. Errors in Counting Platelets in Hemodialysis Patients by Use of Optical Microscopy. Review of Applied Physics (RAP) Volume 2 Issue 1, March 2013; p: 17-22
13. Aurelian Udristioiu¹, Radu Iliescu ², Manole Cojocaru³. Energetic Levels of Metabolic Pathways in Malignant B and T Cells Mini-Review. Advances in Chemical Science Volume 2 Issue 4, December 2013; 2; 90-95
14. Aurelian Udristioiu¹, Manole Cojocaru² Hemolytic Anemia Drugs Induced by Antihypertensive Agents: A case of Laboratory. 13 Scholars Journal of Medical Case Reports ISSN 2347- 6559. Sch J Med Case Rep 2013; 1(1):8-11
15. Aurelian Udristioiu1*, Radu G. Iliescu2, Manole Cojoraru Molecular mechanisms of bone reconstruction in new dental implant technology. Integrated Journal of British. Volume 1 2014 Issue 1(5-6), pg: 1-7; IJBRITISH.

WRITEN BOOKS:

1.Aurelian Udristioiu. “Fitness Bike and Health”. Ed. Medicala 1990, Bucuresti. ISBN: 973-39-01105-9; Formatul 16/10 x 100; Nr pagini: 78.

2.Aurelian Udristioiu. “Bioenergetics of malign and normal cells” Ed. Academica Brancusi 2002, Targu Jiu, Bun de tipar, Bucuresti, Tipografia Everest 2001; ISBN 973 85342-6-7; Formatul 16/14 x 100; Nr. Pagini: 307.

3. Aurelian Udristioiu, Manole Cojocaru, Radu Iliescu., “Hematological and Metabolic Aspects from Laboratory Medicine" (ISBN 978-3-8473-0775-4). LAP LAMBERT Academic Publishing GmbH & Co. KG Heinrich-Böcking-Str. 6-8 , 66121, Saarbrücken, Germany, 2012.

4. Book title: Renal Diseases / Book 2 (ISBN 979-953-307-704-7). Chapter title: Variability of Biological Parameters in Blood Samples between Two Consecutive Schedules of Hemodyalsis
Authors: Aurelian Udristioiu, Manole Cojocaru, Victor Dumitrascu, Daliborca Cristina Vlad, Alexandra Dana Maria Panait and Radu Iliescu, Publishing Group 2011.
Volume 2, Issue 4 (JULY 2011)

5. e-BOOK: Hematological and Metabolical Aspects of Laboratory Medicine (Hematological and Metabolical Aspects from Laboratory Medicine) ( Second Edition ) [Large Print] [Paperback].
Publisher: Aurelian Udristioiu; 2 edition (September 9, 2013); Full Color on White paper, 122 pages. ISBN-13: 978-1492186816

6. Book:” Recent Developments in Biotechnology, Volume 9: Diseases and Theranostics”, Author: Surender Singh. Chapter 21, Energetic Levels of Metabolic Pathways in Malignant B and T Cells Mini-review, Author Aurelian Udristioiu, Manole Cojocaru, ISBN: 9781626990241, Pages: 530, Publisher: Studium Press LLC, Year: 2014

TEACHING RESPONSIBILITIES:

Speciality/area of responsibility From: (Month,Year) To:
(Month,Year)
Lab Director of Laboratory Analyses August 1998 April 2015
REFERENCES
Manole Cojocaru
Titu Maiorescu University, Faculty of Medicine, Physiology Department, Bucharest, Romania; 0723326663 manole.cojocaru@yahoo.com

Dana Alexandra Maria Panait Titu Maiorescu University, Faculty of Medicine, Microbiology Department, Bucharest, Romania 0720949055 dana2pan@yahoo.com

flag Details:
License to practice in: EUROPEN UNION-EU
Certificate of Conformity, Number: NO. VIII. d / 55001 / 19. 10. 2007
BUCHAREST, ROMANIA.

SUMMARY OF EXPERIENCE- BY SKILL
Skill Number of procedures undertaken: From: (Month,Year) To:
(Month,Year)
Perform and Validation of Laboratory Analyses 5000 per month August, 1998 May, 2012
Works of researches, in Laboratory medicine field 11 August, 1998 May, 2012

RESEARCH AND PUBLICATIONS:

Author/s Title Date
1. Udristioiu A. The Assessment of Uncertainty in Measurement of Cholesterol; A Model of Calculation. Biophysical Journal; Volume 96, Issue 3, Supplement 1, Page 504a.
February 2009

2. Udristioiu A, Florescu Cristina, Popescu Manuela Andrei
-High Concentration of anaerobic ATP implicated in aborted apoptosis from CLL”. LabMedicine, American Journal of Clinical Pathology-ASCP , Manuscript 09-08-LM-S-SCI-0122R1, Published in 04-05/2010.

3. Udristioiu A, Cojocaru M, Florescu C. 5. MANUELA-ANDA RADU-POPESCU1*, SILVIA DUMITRIU2,SIMONA ENACHE-SOARE3, GABRIELA BANCESCU2, AURELIANUDRISTOIU4, MANOLE COJOCARU5, CODRUTA VAGU6. 6. MANUELA-ANDA RADU-POPESCU1*, SILVIA DUMITRIU2, SIMONA ENACHE-SOARE3, AURELIAN UDRISTOIU4.

4 Udristioiu A.. -. PHENOTYPIC AND GENOTYPIC CHARACTERIZATION OF ANTIBIOTIC
RESISTANCE PATTERNS IN ACINETOBACTER BAUMANNII STRAINS ISOLATED IN A ROMANIAN HOSPITAL

5. Udristioiu A, Cojocaru M, Florescu C. 5. MANUELA-ANDA RADU-POPESCU1*, SILVIA DUMITRIU2,SIMONA ENACHE-SOARE3, GABRIELA BANCESCU2, AURELIANUDRISTOIU4, MANOLE COJOCARU5, CODRUTA VAGU6. 6. MANUELA-ANDA RADU-POPESCU1*, SILVIA DUMITRIU2, SIMONA ENACHE-SOARE3, AURELIAN UDRISTOIU4Moleular Biological Techiniques user for identification of Candida SPP

6. Aurelian Udristioiu. Identification of Infrared Spectrum from Human Bio-Energetic Campus. Volume 98, Issue 3, Supplement 1, January 2010, Pages 592a


7. Aurelian Udristioiu¹, Manole Cojocaru². First Hematological Signal of Latent Anemia to Aging Population. Nature Publishing Group. Advance Search 0.1038 npre


8. Aurelian Udristioiu¹, Manole Cojocaru -Screening Tests for Latent Anemia in Hospitalized Adults Over 65. LabMedicine, American Journal of Clinical Pathology-ASCP, Manuscript 09-11-LM-S-SCI-0156.R1, Published in 07-05/2010.USA American Journal of Clinical Pathology p-ISSN: 0002-9173 ICV 38.53 LabMedicine

9. Aurelian Udristioiu¹, Manole Cojocaru Variability of bilirubin values in serum samples with high triglycerides; interference or congenital liver syndromes. J Biosci Tech 2011.

10. Aurelian Udristioiu¹, Manole Cojocaru. A new approach of abnormal apoptosis as a cause of autoimmunity and malignancy. Biotech and Molecular Biol.
Aurelian Udristioiu¹, Manole Cojocaru Relation between LDH and Mg as Factors of Interest in the Monitoring and Prognoses of Cancer. Journal of Bioanalysis & Biomedicine.

11. Aurelian Udristioiu¹, Manole Cojocaru - Alkaline Phosphatase Isoenzymes and Leukocyte Alkaline Phosphatase Score in Patients with Acute and Chronic Disease: A Brief Review 2012

12. Aurelian Udristioiu¹, Manole Cojocaru Measurements of mineral elements and heavy metals from hair cells by IPC-Mass Spectrometry ournal of Medical Safety/ July /2013, Tokio , Japan; ISSN: 1349-5232

13. Aurelian Udristioiu¹, Manole Cojocaru Errors in Counting Platelets in Hemodialysis Patients by Use of Optical Microscopy. Review of Applied Physics (RAP) Volume 2 Issue 1, March 2013; p-17-22.


14 -Poster T-400,. A. Udristioiu¹, M. Cojocaru², F. Mitu³. MEASUREMENTS OF MINERAL ELEMENTS AND HEAVY METALS FROM HAIR CELLS BY IPC-MASS SPECTROMETRY. EuroMEdLab; 19-23-05/2013, Abstract: pg. S491. Volume 98, Issue 3, Supplement 1, January 2010, Pages 592a


15. Identification of Infrared Spectrum from Human Bio-Energetic Campus
Aurelian UdristioiuEmergency County Hospital Targu Jiu, Targu Jiu, Romania
Available online 26 January 20103065-Pos
http://dx.doi.org/10.1016/j.bpj.2009.12.

16. Aurelian Udristioiu¹, Manole Cojocaru Energetic Levels of Metabolic Pathways in Malignant B and T Cells Mini-Review 2009.3285.1. Creative Common Attribution 3.0


17. Aurelian Udristioiu¹, Manole Cojocaru Magnesium Research 2011; 24 (1): 22-6. Issue 4 (JULY 2011). November 2011 Vol. 6(8), pp. 166-171. -JBABM-11-48R1 accepted on Jan 27, 2012


TEACHING RESPONSIBILITIES:

Speciality/area of responsibility From: (Month,Year) To:
(Month,Year)
Lab Director of Laboratory Analyses August 1998 May 2012 and in present

WRITEN BOOKS:

1.Aurelian Udristioiu. “Fitness Bike and Health”. Ed. Medicala 1990, Bucuresti. ISBN: 973-39-01105-9; Formatul 16/10 x 100; Nr pagini: 78.

2.Aurelian Udristioiu. “Bioenergetics of malign and normal cells” Ed. Academica Brancusi 2002, Targu Jiu, Bun de tipar, Bucuresti, Tipografia Everest 2001; ISBN 973 85342-6-7; Formatul 16/14 x 100; Nr. Pagini: 307.

3. Aurelian Udristioiu, Manole Cojocaru, Radu Iliescu., “Hematological and Metabolic Aspects from Laboratory Medicine" (ISBN 978-3-8473-0775-4). LAP LAMBERT Academic Publishing GmbH & Co. KG Heinrich-Böcking-Str. 6-8 , 66121, Saarbrücken, Germany, 2012.

4. Book title: Renal Diseases / Book 2 (ISBN 979-953-307-704-7). Chapter title: Variability of Biological Parameters in Blood Samples between Two Consecutive Schedules of Hemodyalsis
Authors: Aurelian Udristioiu, Manole Cojocaru, Victor Dumitrascu, Daliborca Cristina Vlad, Alexandra Dana Maria Panait and Radu Iliescu, Publishing Group 2011.
Volume 2, Issue 4 (JULY 2011)

5. e-BOOK: Hematological and Metabolical Aspects of Laboratory Medicine (Hematological and Metabolical Aspects from Laboratory Medicine) ( Second Edition ) [Large Print] [Paperback].
Publisher: Aurelian Udristioiu; 2 edition (September 9, 2013); Full Color on White paper, 122 pages. ISBN-13: 978-1492186816
(CreateSpace-Assigned); ISBN-10: 1492186813; BISAC: Medical / Laboratory Medicine, USA. Sold by www.amazon.com
Please, see the Blog of my Medical Book :

http://aurelianudristioiu.blogspot.com

NATIONAL AND INTERNATIONAL AWARDS

- Aurelian Udristioiu, National Academy of Biochemical Chemistry
American NACB Member, 2005, Washington D.C, USA.
- Aurelian Udristioiu. Anti-miocard Antibodies in Rheumatic Fever, Measured by Immunofluorescence, Medical Days, Craiova – May 1983. – Premium III Diploma.
- Aurelian Udristioiu. International Travel Grant AACC: Winner/56-th Annual Meeting AACC, 08/25-29/2004, Los Angeles, California, USA.
-Aurelian Udristioiu. International Travel Grant AACC, Winner/57-th Annual Meeting AACC, 07/24-28/2005, Orlando (FL), USA.
- Aurelian Udristioiu. Award: Clinical Chemist`s Recognition Award/2007-2008 and Award/2009, AACC, Washington al Society, since 2008, Columbus, (OH), USA..
-Aurelian Udristioiu, ‘ Who is Who in Romania/2009’ -Romanian Personality in Book Enciclopedy
-Aurelian Udristioiu. Award: Clinical Chemist`s Recognition Award/2007-2008 and Award/2009, AACC, Washington .
- Aurelian Udristioiu, ‘ Who is Who in medical departments USA/ 2011-2012: Who's Who in Medicine and Healthcare 2011-2012 (8th Edition)
” MarquisWho'sWho” , 300 ConnellDrive, Suite 2000, Berkeley Heights, N0: 07922 USA
1-908-673-1000 , www.marquiswhoswho.com

REFERENCES:

Name: Hospital: Contact phone number: Email address:
Manole Cojocaru
Titu Maiorescu University, Faculty of Medicine, Physiology Department, Bucharest, Romania; 0723326663 manole.cojocaru@yahoo.com

Dana Alexandra Maria Panait Titu Maiorescu University, Faculty of Medicine, Microbiology Department, Bucharest, Romania 0720949055 dana2pan@yahoo.com
University of Medicine (Faculty of General Medicine)
Carol Davila, 7000 Bucharest (Romania)







Understanding Speaking W r i t i n g
Listening Reading Spoken interaction Spoken production
A2 Basic User B1 Independent user A2 Basic User A2 Basic User A2 Basic User
(*) Common European Framework of Reference (CEF) level


Medical and Clinical Researches of Biochemistry and Laboratory Analysis

Medical and Clinical Researches of Biochemistry and Laboratory Analysis

Medical and Clinical Researches of Biochemistry and Laboratory Analysis

Medical and Clinical Researches of Biochemistry and Laboratory Analysis

Medical and Clinical Researches of Biochemistry and Laboratory Analysis

Medical and Clinical Researches of Biochemistry and Laboratory Analysis

B






WRITEN BOOKS:

1.Aurelian Udristioiu. “Fitness Bike and Health”. Ed. Medicala 1990, Bucuresti. ISBN: 973-39-01105-9; Formatul 16/10 x 100; Nr pagini: 78.

2.Aurelian Udristioiu. “Bioenergetics of malign and normal cells” Ed. Academica Brancusi 2002, Targu Jiu, Bun de tipar, Bucuresti, Tipografia Everest 2001; ISBN 973 85342-6-7; Formatul 16/14 x 100; Nr. Pagini: 307.

3. Aurelian Udristioiu, Manole Cojocaru, Radu Iliescu., “Hematological and Metabolic Aspects from Laboratory Medicine" (ISBN 978-3-8473-0775-4). LAP LAMBERT Academic Publishing GmbH & Co. KG Heinrich-Böcking-Str. 6-8 , 66121, Saarbrücken, Germany, 2012.

4. Book title: Renal Diseases / Book 2 (ISBN 979-953-307-704-7). Chapter title: Variability of Biological Parameters in Blood Samples between Two Consecutive Schedules of Hemodyalsis
Authors: Aurelian Udristioiu, Manole Cojocaru, Victor Dumitrascu, Daliborca Cristina Vlad, Alexandra Dana Maria Panait and Radu Iliescu, Publishing Group 2011.
Volume 2, Issue 4 (JULY 2011)

5. e-BOOK: Hematological and Metabolical Aspects of Laboratory Medicine (Hematological and Metabolical Aspects from Laboratory Medicine) ( Second Edition ) [Large Print] [Paperback].
Publisher: Aurelian Udristioiu; 2 edition (September 9, 2013); Full Color on White paper, 122 pages. ISBN-13: 978-1492186816

NATIONAL AND INTERNATIONAL AWARDS

- Aurelian Udristioiu, National Academy of Biochemical Chemistry American NACB Member, 2005, Washington D.C, USA.
- Aurelian Udristioiu. Anti-miocard Antibodies in Rheumatic Fever, Measured by Immunofluorescence, Medical Days, Craiova – May 1983. – Premium III Diploma.
- Aurelian Udristioiu. International Travel Grant AACC: Winner/56-th Annual Meeting AACC, 08/25-29/2004, Los Angeles, California, USA.
-Aurelian Udristioiu. International Travel Grant AACC, Winner/57-th Annual Meeting AACC, 07/24-28/2005, Orlando (FL), USA.
- Aurelian Udristioiu. Award: Clinical Chemist`s Recognition Award/2007-2008 and Award/2009, AACC, Washington al Society, since 2008, Columbus, (OH), USA..
-Aurelian Udristioiu, ‘ Who is Who in Romania/2009’ -Romanian Personality in Book Enciclopedy
-Aurelian Udristioiu. Award: Clinical Chemist`s Recognition Award/2007-2008 and Award/2009, AACC, Washington .
- Aurelian Udristioiu, ‘ Who is Who in medical departments USA/ 2011-2012: Who's Who in Medicine and Healthcare 2011-2012 (8th Edition)
” MarquisWho'sWho” , 300 ConnellDrive, Suite 2000, Berkeley Heights, N0: 07922 USA
1-908-673-1000 , www.marquiswhoswho.com

Publicații selectate:

* Aurelian Udristioiu, Role of P53 gene in oncogenenesis of Chronic Lymphocytic Leukemia, Conference: International Symposium on Clinical Neuroscience: Clinical Neuroscience for Optimization of Human Function, onference Abstract: International Symposium on Clinical Neuroscience:, Frontier Front. Neurol., Clinical Neuroscience for Optimization of Human Function., 2016.

* Aurelian Udristioiu¹, Radu G. Iliescu, ² Manole Cojoraru³ ¹Department of Hematology, Emergency County Hospital Târgu Jiu, Clinical Laboratory, Gorj, Romania, aurelianu2007@yahoo.com ²Department of Researches, Polytechnic Institute of New York University, Brooklyn, New York, radugiliescu@yahoo.com ³Titu Maiorescu University, Medicine Faculty, Physiology, Bucharest, E-mail: mancojocaru@yahoo.com ABSTRACT The aim of this work is to illustrate a difficult diagnostic in vitamin B12 deficiency because of using of multivitamin preparations to a patient with unknown etiology of anemia. History: a 70 year old engineer, following 8 years vegetable – dietary, was admitted to the county hospital, in neurology department, with diagnostic of poli-radiculonevrites, received in ward the treatment with milgama (containing 250 micro-gram multivitamin). After a lipotimia status the patient was transferred to cardiology department. Laboratory examinations showed in peripheral blood: Hb = 6 3 g/dl; Ht = 18.8%; RBC= 290.000/mm³; PLT. = 214000/mm³; WBC = 5300/³mm; Ret. = 3, 7%; Erythrocytes indices = normal values; ESR = 38 mm/h, moderate increase and serum iron decreased, 36 microgram/dl value. On blood smear in optic microscopy was registered: Band = 5% (with nucleus in ring!!!), differential count being normally with aspect flags on Coulter HMX Analyzer with 22 parameters: neutrophilia, lymphopenia, anemia. To microscopic examination of slide from bone morrow, have occurred the hyperplasic series of erythrocytes ~ 45%, deficiency of erythropoiesis, poly-cromathopil and acidophil erythroblasts with megaloblastic character, large metamielocytes and giant band forms. Macrocytes and ovalocytes where also presented. Biopsy results from gastric mucosa showed lesions of chronic gastritis, non-atrophic epithelium. Conclusions: Megaloblastosis appears in some time with vitamin B12 deficiently in bone morrow but no in peripheral blood because of administration of multivitamin drugs, deleting haematological shape of megaloblastic anemia. Keywords: Wait blood cells, Erythrocyte sedimentation ratio, haptocorin, transcobalamin. COVER LETTER FOR SUBMISSION OF MANUSCRIPT Open Access Pub – International Journal of Nutrition COVER LETTER FOR SUBMISSION OF MANUSCRIPT Date: 13/05/2016 I am enclosing herewith a manuscript entitled “ANEMIA BY VITAMIN B12 AND LATENT IRON DEFICIENCY ” in Journal International Journal of Nutrition for publication in for possible evaluation. The Corresponding author of this manuscript is Aurelian Udristioiu , ¹Department of Hematology, Emergency County Hospital Târgu Jiu, Clinical Laboratory, Gorj, and contribution of the authors as mentioned below with their responsibility in the research. 1. Radu G. Iliescu, ²Department of Researches, Polytechnic Institute of New York University, Brooklyn, New York 2. Manole Cojoraru, ³Titu Maiorescu University, Medicine Faculty, Physiology, Bucharest With the submission of this manuscript I would like to undertake that: • All authors of this research paper have directly participated in the planning, execution, or analysis of this study; • All authors of this paper have read and approved the final version submitted; • The contents of this manuscript have not been copyrighted or published previously; • The contents of this manuscript are not now under consideration for publication elsewhere; • The contents of this manuscript will not be copyrighted, submitted, or published elsewhere, while acceptance by the Journal is under consideration; • There are no directly related manuscripts or abstracts, published or unpublished, by any authors of this paper; • My Institute’s (Put name of your institute here) representative is fully aware of this submission. Submitted manuscript is a Research Article (Ex: Research Article, Review Article, Short Communication, Letters, Editorials) The research project was conducted under the supervision of: , ¹Department of Hematology, Emergency County Hospital Târgu Jiu, Clinical Laboratory, Gorj, Romania This research project was conducted from ___05/05/2016______________ to _13/05/2016_________________ Starting date Ending date From the same project I have already published the following manuscripts: If any Book:Hematological and Metabolical Aspects of Laboratory Medicine (3-th Edition/2016). Publisher: Aurelian Udristioiu. http://aurelianudristioiu.blogspot.com My Research Project was partially or fully sponsorised (n/a) with grant number (n/a). If you have undergone your research project without any financial assistance, then you must provide information who was the sponsor of the project? Please suggest potential three reviewers for this submission. (OPTIONAL) Use the fields below to give us contact information for each suggested reviewer, and please provide specific reasons for your suggestion in the comments box for each person. Please note that the journal may not use your suggestions, but your help is appreciated and may speed up the selection of appropriate reviewers. Reviewers' field: No. 1: First Name Dana Middle Initial Last Name Panait Academic Degree(s) PhD Position Researcher Department Microbiology Institution National Agency of Drugs, Bucharest E-mail Address Dana2pan@yahoo.com Reason Scientific No. 2: First Name Dali Middle Initial Last Name Vlad Academic Degree(s) MD Position Lab Director Department Clinical Trial Institution Central Laboratory Synevo, Bucharest E-mail Address dalivlad@yahoo.com Reason Scientific No. 3: First Name Sorin Middle Initial Last Name Giju Academic Degree(s) PhD Position Chief in Biochemistry Department Department Biochemistry Institution Emergency Hospital University Timisoara, Romania E-mail Address soringiju@yahoo.com Reason Scientific Date: 13/05/2016 ___________Aurelian Udristioiu______________________________________ (Signature of corresponding author on behalf of all authors) (A scanned signature is valid) Introduction Deficiency of vitamin B12 was a disease that has intrigued numerous investigators for many years. In fact, the history of pernicious anaemia was an “illustrative case” of the development and progress of medicine. The aim of this work was to illustrate, by one difficult case patient, admitted in hospital, the diagnosis of B12 vitamin deficiency, intrigued with iron deficiency, because of multivitamin drugs, used as an individual treatment of patient, without a previous medical consult.. History: A 70 year old engineer, since 8 years vegetable – diet, was admitted to the county hospital in month august 20 – 2011, because of weakness, 10 kilo in last two months], dizziness, exertional dyspneea, ataxia and numbress of the hands, with lung disease in evolution. After screening investigations without a concluded diagnosis, in 10 - 20 September/2012, was transferred to department of neurology because of symptoms came to include a loss of sensitivity in extremities, paresthesia, an unsteady gait [ataxia] and loss of balance. Psychiatric symptoms such as memory disturbance, depression and cognitive decline have been also reported. For a presumptive diagnosis of poly-radiculonevrites, the patient followed treatment with milgama, contained ciancobalamin vitamin 250 microgr /vial, prednisone, levomepromazin, antibiotics. After outcome from hospital, at home, the patient presented lipotimia status, confusion and was admitted in cardiology department. Laboratory blood – CBC – showed: HGB = 6.3 g/dl; HTC = 18.8%; RBC = 290.000/³mm, Thrombocyte = 214000/.mm³, WBC = 5300/³mm; Reticulocyte = 3.7%; Erythrocyte indices = normal values. On blood smear in optic microscopy: Band = 5% [nucleus in ring!?], Segmented = 75%, Eosinophile = 1%; Basophile = 1%, Lymphocyte = 11%, Monocyte = 3%, ESR = 38 mm/h.; Suspect flags on coulter HMX. Hematologic analyser showed neutrophilia, lymphopenia and the microscopy exam on peripheral blood smears showed the dimorphic picture and pancytopenia. Macropolicytes and ovlaocytes were also presented, Other laboratory tests relieved an increased level LDH = 710 u/l [N = 313 – 618], glucose = 143 mg/dl [N = 75 – 110], urea = 111 mg/dl, creatinine = 1,3 mg/dl, triglyceride = 251 mg/dl [20 – 150], iron = 35 ug/dl [N = 49 – 181], serum ferritn = 15 ng/ m l, Total bilirubin < 0,2 mg/dl and Indirect bilirubin = 0,1 mg/dl, ALT and AST with normal values. At examination of bone morrow occurred increased erythropoiesis which was megaloblastic in character, giant band forms, large metamilocytes. In conclusion, bone morrow with hyperplasic series erythrocytes ~ 45%, deficiency of erythropoiesis [predominant acidophil and policromatophil erythroblasts]. Biopsy results from gastric mucosa showed lesions of chronic gastritis, non-atrophic. Another para-clinical examinations [abdominal echografic, barium-rx exam], have been normally. B12 vitamin dosage on the Analyzer Chemi Immulite 2000 in peripheral blood showed 150 pg/m L (biological reference interval =193-982 pg/m L) and folic acid dosage into erythrocytes was in normal value, 1632 nmol/L(biological reference interval =995-2499). Diagnosis: anemia by cobalamin deficiency and iron deficiency The patient followed therapeutic sample [with B12 vitamin, 1000 gamma, im./per day, 2 weeks and than 1000 gamma per week, Omeran 1 tb./day, in morning 10 o’clock, Ferumgradumet 1 tablet/day, protection of diet. Evolution After therapeutic sample, in 10 days, Hb became 9,8 g/dl, Ht = 29%, Reticulocyte = 11% with IP = 3,48, Leucocyte = 5000/cu-mm, Thrombocyte = 281000/cu.mm, ESR = 18 mm/h. The peripheral blood picture showed: Neutrophiles = 73%, Eosinophile = 2%, Basophile = 2%, Monocyte = 15%, Lymphocyte = 8%. The blood smear shows anisocytosis: normocytosis with ease macrocytosis. Urea was normalised = 48 mg/dl, plasma iron = 46 ug/dl, TIBC = 382mg/100 ml, sample of coagulation with normal values [aPTT, fibr, At3, PDF (-), TELCE [-]. In present time the patient there is in treatment with B12 vitamin, 50 gamma/week with the normal level serum ferritin, 122 ng/m L((biological reference interval =25-285 ng/m L for man and 5-148 ng/m L for women. Efficiency of treatment in periodically will be monitored and by performing of metilmalonic acid test (heparnied plasma) and homocystein level (EDTA plasma). Comment: In first time the neurogical manifestation occurred to patients in absence of blood picture in peripheral blood of typical megaloblastic anemia. To the patient with vegetable diet anemia by B12 vitamin is accompanied of neurological syndrome with frequently iron deficiency, specialty to elder men. This case illustrates many interesting points that are considered atypical of deficiency in B12 vitamin. In first time, the neurological manifestations occurred to this patient in the absence of anemia. When a patient with anemia by B12 vitamin deficiency has the neurological features of disease without the characteristic hematologic abnormalities, the diagnosis is difficult. On such circumstance, the patient has received B12 vitamin and folic acid in an amount that is sufficient to convert the megaloblastic anemia type of erythropoiesis to the normoblastic type in peripheral blood and raise the erythrocyte count. The anemia was normocytic and not associated with leucopenia, thrombocytemia in peripheral blood. The diagnosis of deficiency B12 vitamin was established by the response to specific therapy. When and iron deficiency is severe the anemia is hypochromic and microcytic but in milder degrees of iron deficiency the anemia is normocytic. A combined deficiency of iron B12 vitamin might result in a normocytic anemia that required both iron and vitamin B12 in treatment [1]. Impaired absorption of vitamin B12 occurs and in other conditions different of diet deficiencies associated with diarrhea or other evidence of the mal-absorption syndrome. Such impairment has been demonstrated to patients with: - Blind intestinal loops, fistulae, strictures, and diverticula of the small bowel, - Gastrectomy, because absence of the gastric intrinsic factor, altered gastric secretion, gastric atrophy with degenerative lesions, mal-absorption syndrome, gastro duodenal disease and pancreatic, abnormal bacterial proliferations in bowel, infestation with parasites, failure pancreatic, liver, chronic hepatitis cirrhosis, - Disease of lymphoma group, myeloproliferative syndrome (MSD) by elevated consummations in neoplasia and hyperthyroid – but a study of the bone morrow usually enable one to establish the diagnosis [2]. In some patient particularly since the advent of folic acid and the widespread use of multivitamin preparations the aematological abnormalities are mild or absent when neurological manifestations are predominant. The bone morrow is usually hyper-cellular. The characteristic feature is the occurrence of the megaloblastic type of erythropoiesis. If anemia is severe, promegaloblastic and basophilic megaloblasts are increased in number and mitotic divisions are numerous [3]. The polychromatophilic megaloblasts which are easiest cells to identify in this serious persist even after the anemia in the peripheral blood has been abolished by transfusion. Deficiency of vitamin B12 or folic acid also leads to the production of giant metamielocytes and multi-segmented macropolicites. The abnormalities in the granulocytic series do not disappear as promptly as then megaloblasts after specific therapy and their present may be helpful in diagnosis. There are the conversion of the megaloblastic type of erythropoiesis to the normoblastic type within two day, a rise in reticolocytes during the first week, and a return of the haemoglobin and red count to normal levels in succeeding weeks. The absorption of the vitamin may be affected by atrophic gastritis [around 20% individuals over 60 years this conditions [4]. The recent years the picture has become more complex. For example: 24 – 28% of patients do not have anemia, 17 – 33% have a normal mean corpuscular volume [MCV], there is an apparent normal cobalamin levels to patients with clinical evidence of deficiency in B12 vitamin [5]. In last time, attention has recently been focused on measuring metabolic levels methylmalonic acid [- MMA -], and homocystein [- Hcy -], as these should accumulate when a deficiency stare exists. However, both of these methabolits can be affected by the renal function of the patient and Hcy can be elevated when there is an underling folate deficiency [6]. The situation becomes more warring when abnormal levels of metabolites are detected but the total Hcy are apparently well within normal range. The notion that metabolic levels change before that total Cbl levels decreases this fact not proven. Current made techniques for measuring plasma Cbl that is bond to both haptocorin [HC] and transcobalamin [TC], complex describing Holo-Transcobalamin. Hololotranscobalamin has been suggested as a better marker for cobalamin deficiency because of: - measures the physiologically relevant fraction of circulating cobalamin, -It has a short-life and so may be a good early good marker. It is hoped that the new methods [antibodies and physico-chemical methods] will be enable to the investigators to address the many questions surrounding holo-trancobalamin and also enable carefully designed clinical surveys to be undertaken [7]. Conclusions: To the vegetarian elder men, anemia by deficiency of B12 vitamin is accompanied of neurological syndrome. There are frequent and deficiency of iron also to the patient which eats vegetal reached in folic acid, cofactor of B12 vitamin, but poor in B12 vitamin. Megaloblastoza appears in same time with B12 vitamin deficiency, in bone morrow but not in peripheral blood. Neuropathy was results from accumulations of a metabolised metylmalonic acid [from propionic acid] with decrease of acetyl-coA, ATP and energy cells. Drugs with poli-vitamins administrated without corresponding investigations can delete haematological shape of megaloblastic anemia. References [1] William S. Beck, the book: Haematology – Fourth Editions, Lecture 4, “Megaloblastic Anemias”, WH, USA 1990. [2] Carmel R. Current Measuring and Interpreting Holo – Transcobalamin (Holo-Transcobalamin 11). (Editorial), Clinical Chemistry 2002; (48); 3: 407-408. [3] Ulleland M. Direct Assay for Cobalamin Bound to Transcobalamin (Holo-Transcobalamin) in Seum, Clinical Chemistry 2002; (8); 3: 526 – 532. [4] Nexo E. Quantification of Transcobalamin, a Marker of Vitamin B 12 Deficiency. Clinical Chemistry 2004; (8); 3: 561-562. [5] Association of Cognitive Impairment with Combination of Vitamin B12-Related Parameters. Clinical Chemistry 2011; (57); 10: 1436-1443. [6] Bennett J M. Practical Diagnosis of Hematological Disorders.2th ed. Lett. Anemia of Chronic Diseases. Chicago: ASCP Press 2006; p. 615 – 671 [7] Steensma DP, Tefferi A. Anemia in the elderly: how should we define it, when does it matter, and what can be done?. Mayo Clin Proc 2007; 82(8): 958-66., ANEMIA BY VITAMIN B12 AND LATENT IRON DEFICIENCY, International Journal of Nutrition, Submitted manuscript is a Research Article.

* , Metode pentru prevenirea Sindromului Metabolic.

* , Apoptoza si autoimunitatea in neoplasmele hematologice.

* Aurelian Udristioiu¹, Staniloiu Mihail¹, Manole Cojocaru², Sorina Comisel³, Molecular mechanisms of bone reconstruction in new dental implant technology, © PSCI Publications, © PSCI Publications, Applied Science Reports, 10 (2), 2015, 2015.

* Aurelian Udristioiu, Manole Cojocaru, Rapid Diagnosis by Multiplex PCR Technology at Patients with Acute Respiratory Infections, American Association for Science and Technology AASCIT Communications, American Association for Science and Technology AASCIT Communications, American Association for Science and Technology AASCIT Communications, Volume 1, Issue 3 October 20, 2014 online, 2014.

* Aurelian Udristioiu, Manole Cojocaru, Victor Dumitrascu, Daliborca Cristina Vlad, Alexandra Dana Maria Panait and Radu Iliescu, Variability of Biological Parameters in Blood Samples between Two Consecutive Schedules of Hemodyalsis, Publishing Group 2011., Renal Diseases / Book 2 (ISBN 979-953-307-704-7)., 2, 2011.

* Aurelian Udristioiu, Hematological and Metabolical Aspects of Laboratory Medicine , 2013.

* Aurelian Udristioiu, Manole Cojocaru, Radu Iliescu, Hematological and Metabolic Aspects from Laboratory Medicine, LAP LAMBERT Academic Publishing GmbH & Co., LAP LAMBERT Academic Publishing GmbH & Co., 2012.

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